PMID- 19728011
OWN - NLM
STAT- MEDLINE
DCOM- 20100208
LR  - 20211020
IS  - 1437-7799 (Electronic)
IS  - 1342-1751 (Linking)
VI  - 13
IP  - 6
DP  - 2009 Dec
TI  - Rapid deterioration of renal function in a patient with multiple myeloma 
      associated with amyloid and light chain depositions.
PG  - 671-6
LID - 10.1007/s10157-009-0221-3 [doi]
AB  - Here we report a 75-year-old man with multiple myeloma who developed acute 
      deterioration of renal function. Systemic AL amyloid deposition was found in the 
      stomach, duodenum and brachial artery. A small amount of proteinuria without 
      significant abnormal urinary sediments, increased excretion of urinary 
      low-molecular-weight proteins and Bence Jones protein were observed. Significant 
      renal Ga-67 uptake suggested acute tubulointerstitial lesions. Renal necropsy 
      after sudden death 40 days after introduction of hemodialysis revealed mesangial 
      expansion with glomerular basement membrane thickening, tubular basement membrane 
      thickening with or without tubular atrophy and massive tubulointerstitial 
      fibrosis. Slight amyloid depositions in the mesangium and vessels, and massive 
      granular electron-dense deposits and deposition of monoclonal light chain lambda 
      in renal basement membranes and vessels were found, indicating the rare condition 
      of coexistence of amyloidosis and light chain deposition disease(LCDD). The rapid 
      progression of renal failure may have been caused by massive deposition of 
      monoclonal light chains in our patient.
FAU - Nakayama, Naoko
AU  - Nakayama N
AD  - The First Department of Medicine, Hamamatsu University School of Medicine, 
      Higashi-ku, Hamamatsu, Japan.
FAU - Fujigaki, Yoshihide
AU  - Fujigaki Y
FAU - Tsuji, Takayuki
AU  - Tsuji T
FAU - Sakakima, Masanori
AU  - Sakakima M
FAU - Yasuda, Hideo
AU  - Yasuda H
FAU - Togawa, Akashi
AU  - Togawa A
FAU - Suzuki, Hiroyuki
AU  - Suzuki H
FAU - Fujikura, Tomoyuki
AU  - Fujikura T
FAU - Kato, Akihiko
AU  - Kato A
FAU - Baba, Satoshi
AU  - Baba S
FAU - Takahashi, Satoru
AU  - Takahashi S
FAU - Hishida, Akira
AU  - Hishida A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
RN  - 0 (Amyloid)
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Acute Kidney Injury/*etiology/pathology
MH  - Aged
MH  - Amyloid/*metabolism
MH  - Amyloidosis/complications
MH  - Death, Sudden/pathology
MH  - Fatal Outcome
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Kidney/pathology
MH  - Male
MH  - Multiple Myeloma/*complications
EDAT- 2009/09/04 06:00
MHDA- 2010/02/09 06:00
CRDT- 2009/09/04 06:00
PHST- 2009/03/01 00:00 [received]
PHST- 2009/07/20 00:00 [accepted]
PHST- 2009/09/04 06:00 [entrez]
PHST- 2009/09/04 06:00 [pubmed]
PHST- 2010/02/09 06:00 [medline]
AID - 10.1007/s10157-009-0221-3 [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2009 Dec;13(6):671-6. doi: 10.1007/s10157-009-0221-3.