PMID- 19728026
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20211020
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 90
IP  - 3
DP  - 2009 Oct
TI  - Plasma cell leukemia producing monoclonal immunoglobulin E.
PG  - 402-406
LID - 10.1007/s12185-009-0407-1 [doi]
AB  - A 78-year-old male with lumbar pain and dim consciousness presented the clinical 
      pictures of plasma cell leukemia (PCL) producing a large amount of monoclonal 
      immunoglobulin E (IgE)/kappa protein. Laboratory investigation demonstrated an 
      elevated serum calcium level and renal dysfunction. Systemic bone X-ray survey 
      disclosed only a solitary osteolytic lesion. Circulating plasma cells 
      demonstrated CD19(-)/CD56(-) and MPC-1(-)/CD49e(-)/CD45(+/-), the latter 
      indicating the immature phenotype of the tumor cells. Bone marrow was occupied 
      with immature, atypical plasma cells, of which cytoplasms were positive for IgE 
      by direct immunofluorescence analysis. Chromosomes revealed a translocation of 
      (11;14)(q13;q32), which is concordant with cyclinD1-protein overexpression by 
      immunohistochemistry. He was treated with dexamethasone and vincristine, which 
      somewhat improved the laboratory findings. He died of tumor progression after 
      4-month admission. The clinical and biological characteristics of IgE-producing 
      PCL, a very rare type of plasma cell dyscrasia, are discussed, reviewing the past 
      literature.
FAU - Takemura, Yuzuru
AU  - Takemura Y
AD  - Department of Clinical Laboratories, Saku Central Hospital, 197 Usuda, Saku, 
      Nagano, 384-0301, Japan. yuzurutakemura@nifty.com.
AD  - Department of Internal Medicine, Saku Central Hospital, Saku, Japan. 
      yuzurutakemura@nifty.com.
FAU - Ikeda, Masanobu
AU  - Ikeda M
AD  - Department of Clinical Laboratories, Saku Central Hospital, 197 Usuda, Saku, 
      Nagano, 384-0301, Japan.
FAU - Kobayashi, Kahori
AU  - Kobayashi K
AD  - Department of Clinical Laboratories, Saku Central Hospital, 197 Usuda, Saku, 
      Nagano, 384-0301, Japan.
AD  - Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu 
      University, Matsumoto, Japan.
FAU - Nakazawa, Yuji
AU  - Nakazawa Y
AD  - Department of Clinical Laboratories, Saku Central Hospital, 197 Usuda, Saku, 
      Nagano, 384-0301, Japan.
FAU - Mori, Yuichi
AU  - Mori Y
AD  - Department of Internal Medicine, Saku Central Hospital, Saku, Japan.
FAU - Mitsuishi, Toshimi
AU  - Mitsuishi T
AD  - Department of Internal Medicine, Saku Central Hospital, Saku, Japan.
FAU - Ishigame, Hiroki
AU  - Ishigame H
AD  - Department of Clinical Pathology, Saku Central Hospital, Saku, Japan.
FAU - Kameko, Fumiko
AU  - Kameko F
AD  - Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu 
      University, Matsumoto, Japan.
FAU - Fujita, Kiyotaka
AU  - Fujita K
AD  - Department of Medical Crisis Management, Chiba Institute of Science, Choshi, 
      Japan.
FAU - Ichinohasama, Ryo
AU  - Ichinohasama R
AD  - Division of Hematopathology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20090829
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Immunoglobulin kappa-Chains)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aged
MH  - Antibodies, Monoclonal/*blood
MH  - Bone Neoplasms/*immunology/pathology
MH  - Fluorescent Antibody Technique, Direct
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin kappa-Chains/*blood
MH  - Leukemia, Plasma Cell/*immunology/pathology
MH  - Male
RF  - 28
EDAT- 2009/09/04 06:00
MHDA- 2010/04/09 06:00
CRDT- 2009/09/04 06:00
PHST- 2009/05/13 00:00 [received]
PHST- 2009/07/30 00:00 [accepted]
PHST- 2009/07/22 00:00 [revised]
PHST- 2009/09/04 06:00 [entrez]
PHST- 2009/09/04 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - 10.1007/s12185-009-0407-1 [pii]
AID - 10.1007/s12185-009-0407-1 [doi]
PST - ppublish
SO  - Int J Hematol. 2009 Oct;90(3):402-406. doi: 10.1007/s12185-009-0407-1. Epub 2009 
      Aug 29.