PMID- 1972881
OWN - NLM
STAT- MEDLINE
DCOM- 19900808
LR  - 20201209
IS  - 0934-8840 (Print)
IS  - 0934-8840 (Linking)
VI  - 272
IP  - 4
DP  - 1990 Apr
TI  - Restoration of defective cytokine activity within lepromatous leprosy lesions.
PG  - 458-66
AB  - Immunohistological studies of tuberculoid leprosy lesions (TT-lesions) showed a 
      dense, well organized granuloma consisting of a central area with epitheloid and 
      giant cells containing interferon-gamma (IFN-Gamma) and CD3+, CD4+ T 
      helper/inducer (Th/i) cells, a considerable proportion of which expressed the 
      interleukin-2-receptor (IL-2 R). This central area was surrounded by round cells 
      which consisted mainly of CD3+/CD8+ T cytotoxic/suppressor (Tc/s) lymphocytes. 
      The overlying keratinocytes (KC) were strongly positive for HLA-DR antigens on 
      the surface, indicating high intralesional IFN-Gamma activity. In contrast, 
      lepromatous leprosy lesions (LL-lesions) showed a disorganized infiltrate 
      composed by foamy cells and round cells, the latter mainly expressing the 
      CD3+/CD8+ phenotype. IFN-Gamma activity could not be detected within the lesions. 
      The KC overlying the infiltrate were consistently negative for HLA/DR reactivity 
      pointing to a defective intralesional IFN-Gamma production in LL patients. Two 
      out of four patients with LL leprosy could be sensitized with 
      dinitrochlorobenzene (DNCB). The eliciting of DNCB skin reactions within the 
      LL-lesion led to the recruitment of new infiltrating cells; the resulting 
      infiltrate resembled a local reversal towards the tuberculoid pole of leprosy.
FAU - Volc-Platzer, B
AU  - Volc-Platzer B
AD  - Univ. Hautklinik, Wien.
FAU - Kremsner, P
AU  - Kremsner P
FAU - Stemberger, H
AU  - Stemberger H
FAU - Wiedermann, G
AU  - Wiedermann G
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Zentralbl Bakteriol
JT  - Zentralblatt fur Bakteriologie : international journal of medical microbiology
JID - 9203851
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Interleukin-2)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Dendritic Cells/immunology
MH  - Dinitrochlorobenzene/pharmacology
MH  - Foam Cells/immunology
MH  - Granuloma/immunology/pathology
MH  - HLA-DR Antigens/*analysis
MH  - Humans
MH  - Hypersensitivity, Delayed
MH  - Immunity, Cellular
MH  - Immunohistochemistry
MH  - Interferon-gamma/*analysis
MH  - Keratinocytes/*immunology
MH  - Leprosy, Lepromatous/*immunology/pathology
MH  - Leprosy, Tuberculoid/immunology/pathology
MH  - Macrophages/immunology
MH  - Receptors, Interleukin-2/*analysis
MH  - T-Lymphocytes, Helper-Inducer/immunology
MH  - T-Lymphocytes, Regulatory/immunology
EDAT- 1990/04/01 00:00
MHDA- 2000/05/11 00:00
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 2000/05/11 00:00 [medline]
PHST- 1990/04/01 00:00 [entrez]
AID - 10.1016/s0934-8840(11)80047-2 [doi]
PST - ppublish
SO  - Zentralbl Bakteriol. 1990 Apr;272(4):458-66. doi: 10.1016/s0934-8840(11)80047-2.