PMID- 19728851
OWN - NLM
STAT- MEDLINE
DCOM- 20091112
LR  - 20191210
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 47
IP  - 9
DP  - 2009
TI  - Serum concentrations of extracellular fatty acid synthase in patients with 
      steatohepatitis.
PG  - 1097-9
LID - 10.1515/CCLM.2009.259 [doi]
AB  - BACKGROUND: Fatty acid synthase (FASN) is an enzyme synthesized by the liver and 
      plays an important role in lipogenesis. The present study aimed to assess whether 
      serum FASN concentrations are altered in patients with chronic liver disease, and 
      to investigate whether its measurement may be a useful tool in the clinical 
      evaluation of this derangement. METHODS: We investigated 93 patients with chronic 
      liver disease (14 minimal change disease, 79 steatohepatitis) and 100 control 
      subjects. Serum FASN concentrations were measured using ELISA. RESULTS: Patients 
      had a significant increase in serum FASN concentration (p<0.001), which was 
      specifically associated with the hepatic Knodell sub-index III of portal 
      inflammation (p=0.019). In addition, serum FASN concentrations were significantly 
      correlated with the circulating levels of the monocyte chemoattractant protein-1 
      (MCP-1) (Spearman rho=0.375; p<0.001) and type III procollagen-N-peptide 
      (P-III-P) (Spearman rho=0.297; p<0.001). CONCLUSIONS: Serum FASN concentrations 
      are increased in patients with chronic liver impairment, and are associated with 
      specific histological alterations and biochemical markers of portal inflammation. 
      These data suggest that FASN measurement may contribute significantly to the 
      evaluation of these patients.
FAU - Marsillach, Judit
AU  - Marsillach J
AD  - Centre de Recerca Biomedica, Hospital Universitari de Sant Joan, Institut 
      d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
FAU - Oliveras-Ferraros, Cristina
AU  - Oliveras-Ferraros C
FAU - Beltran, Raul
AU  - Beltran R
FAU - Rull, Anna
AU  - Rull A
FAU - Aragones, Gerard
AU  - Aragones G
FAU - Alonso-Villaverde, Carlos
AU  - Alonso-Villaverde C
FAU - Vazquez-Martin, Alejandro
AU  - Vazquez-Martin A
FAU - Joven, Jorge
AU  - Joven J
FAU - Menendez, Javier A
AU  - Menendez JA
FAU - Camps, Jordi
AU  - Camps J
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Chemokine CCL2)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (procollagen Type III-N-terminal peptide)
RN  - EC 2.3.1.85 (Fatty Acid Synthases)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/blood
MH  - Fatty Acid Synthases/*blood
MH  - Fatty Liver/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptide Fragments/blood
MH  - Procollagen/blood
MH  - Severity of Illness Index
EDAT- 2009/09/05 06:00
MHDA- 2009/11/13 06:00
CRDT- 2009/09/05 06:00
PHST- 2009/09/05 06:00 [entrez]
PHST- 2009/09/05 06:00 [pubmed]
PHST- 2009/11/13 06:00 [medline]
AID - 10.1515/CCLM.2009.259 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2009;47(9):1097-9. doi: 10.1515/CCLM.2009.259.