PMID- 19729047
OWN - NLM
STAT- MEDLINE
DCOM- 20091216
LR  - 20131121
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 313
IP  - 1-2
DP  - 2009 Dec 10
TI  - Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas.
PG  - 1-8
LID - 10.1016/j.mce.2009.08.020 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a heriditary syndrome characterised 
      by the occurrence of parathyroid, gastroenteropancreatic and pituitary tumours. 
      The MEN1 gene product, menin, co-activates gene transcription by recruiting 
      histone methyltransferases for lysine 4 of histone H3 (H3K4). We investigated 
      whether in MEN1 tumours global changes in H3K4 trimethylation (H3K4me3) occur or 
      whether alterations in gene expression can be observed. By immunohistochemistry 
      we found that global levels of H3K4me3 are not affected in MEN1-related 
      parathyroid adenomas. Menin can interact directly with the vitamin D receptor 
      (VDR) and enhance the transcriptional activity of VDR. Messenger RNA levels of 
      VDR target genes CYP24 and KLK6 were significantly lower in MEN1 parathyroid 
      adenomas compared to normal tissue. Thus, aberrant gene expression in MEN1 
      tumours is not caused by lower global H3K4me3, but rather by specific effects on 
      genes that are regulated by menin-interacting proteins, such as VDR.
FAU - Dreijerink, Koen M A
AU  - Dreijerink KM
AD  - Department of Physiological Chemistry, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Varier, Radhika A
AU  - Varier RA
FAU - van Nuland, Rick
AU  - van Nuland R
FAU - Broekhuizen, Roel
AU  - Broekhuizen R
FAU - Valk, Gerlof D
AU  - Valk GD
FAU - van der Wal, Jacqueline E
AU  - van der Wal JE
FAU - Lips, Cornelis J M
AU  - Lips CJ
FAU - Kummer, J Alain
AU  - Kummer JA
FAU - Timmers, H Th Marc
AU  - Timmers HT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090901
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Histones)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Calcitriol)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Gene Expression Regulation
MH  - *Histones/genetics/metabolism
MH  - Humans
MH  - Lysine/*metabolism
MH  - Methylation
MH  - Mice
MH  - Mice, Knockout
MH  - *Multiple Endocrine Neoplasia Type 1/metabolism/pathology
MH  - *Parathyroid Neoplasms/metabolism/pathology
MH  - Proto-Oncogene Proteins/genetics/metabolism
MH  - Receptors, Calcitriol/*metabolism
MH  - Two-Hybrid System Techniques
EDAT- 2009/09/05 06:00
MHDA- 2009/12/17 06:00
CRDT- 2009/09/05 06:00
PHST- 2009/03/15 00:00 [received]
PHST- 2009/07/24 00:00 [revised]
PHST- 2009/08/26 00:00 [accepted]
PHST- 2009/09/05 06:00 [entrez]
PHST- 2009/09/05 06:00 [pubmed]
PHST- 2009/12/17 06:00 [medline]
AID - S0303-7207(09)00454-7 [pii]
AID - 10.1016/j.mce.2009.08.020 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2009 Dec 10;313(1-2):1-8. doi: 10.1016/j.mce.2009.08.020. 
      Epub 2009 Sep 1.