PMID- 19729343
OWN - NLM
STAT- MEDLINE
DCOM- 20100211
LR  - 20131121
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 212
IP  - 6
DP  - 2009 Nov
TI  - GerES IV: phthalate metabolites and bisphenol A in urine of German children.
PG  - 685-92
LID - 10.1016/j.ijheh.2009.08.002 [doi]
AB  - Urine samples from GerES IV were analysed for concentrations of the metabolites 
      of DEHP (MEHP, 5OH-MEHP, 5oxo-MEHP, 5cx-MEPP, and 2cx-MMHP), DnBP and DiBP (MnBP 
      and MiBP), BBzP (MBzP), DiNP (7OH-MMeOP, 7oxo-MMeOP and 7cx-MMeHP), and bisphenol 
      A (BPA) to assess the exposure of German children on a representative basis. 600 
      morning urine samples had been randomly chosen from stored 1800 GerES IV samples 
      originating from 3 to 14 year old children living in Germany. All metabolites 
      could be detected in nearly all urine samples (N=599). Descriptive data analysis 
      leads to mean concentrations of 5-OH-MEHP and 5-oxo-MEHP of 48microg/l and 
      37microg/l, respectively. The mean concentration of 7OH-MMeOP was 11microg/l. 
      MnBP, MiNP, MBzP showed mean levels of 96microg/l, 94microg/l, and 18microg/l, 
      respectively. The concentrations of the phthalate metabolites decreased with 
      increasing age. Compared to German adults all children showed three to five fold 
      higher urine concentrations than adults analysed in the same decade. For some 
      children the levels of the sum of 5OH-MEHP and 5oxo-MEHP in urine were higher 
      than the German human biomonitoring value (HBM I) of 500mcirog/l, which indicates 
      that adverse health effects cannot be excluded for these subjects with sufficient 
      certainty. The mean concentration of BPA in urine was 2.7microg/l. A rough 
      calculation of the daily intakes on the basis of the measured concentrations in 
      urine resulted in daily intakes two orders of magnitude lower than the current 
      EFSA reference dose of 50microg/kgbw/d.
FAU - Becker, Kerstin
AU  - Becker K
AD  - Federal Environment Agency (UBA), Dessau-Rosslau/Berlin, Germany. 
      Kerstin.Becker@uba.de
FAU - Goen, Thomas
AU  - Goen T
FAU - Seiwert, Margarete
AU  - Seiwert M
FAU - Conrad, Andre
AU  - Conrad A
FAU - Pick-Fuss, Helga
AU  - Pick-Fuss H
FAU - Muller, Johannes
AU  - Muller J
FAU - Wittassek, Matthias
AU  - Wittassek M
FAU - Schulz, Christine
AU  - Schulz C
FAU - Kolossa-Gehring, Marike
AU  - Kolossa-Gehring M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090902
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phenols)
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Adolescent
MH  - Benzhydryl Compounds
MH  - Child
MH  - Child, Preschool
MH  - Environmental Monitoring
MH  - Environmental Pollutants/metabolism/*urine
MH  - Germany
MH  - Humans
MH  - Phenols/*urine
MH  - Phthalic Acids/metabolism/*urine
MH  - Population Surveillance
EDAT- 2009/09/05 06:00
MHDA- 2010/02/12 06:00
CRDT- 2009/09/05 06:00
PHST- 2009/06/02 00:00 [received]
PHST- 2009/07/20 00:00 [revised]
PHST- 2009/08/01 00:00 [accepted]
PHST- 2009/09/05 06:00 [entrez]
PHST- 2009/09/05 06:00 [pubmed]
PHST- 2010/02/12 06:00 [medline]
AID - S1438-4639(09)00100-X [pii]
AID - 10.1016/j.ijheh.2009.08.002 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2009 Nov;212(6):685-92. doi: 
      10.1016/j.ijheh.2009.08.002. Epub 2009 Sep 2.