PMID- 1972945
OWN - NLM
STAT- MEDLINE
DCOM- 19900806
LR  - 20190817
IS  - 0192-0790 (Print)
IS  - 0192-0790 (Linking)
VI  - 12
IP  - 3
DP  - 1990 Jun
TI  - Is solitary rectal ulcer a manifestation of a systemic disease?
PG  - 286-90
AB  - In a prospective study of 22 patients with solitary rectal ulcer, we tried to 
      define the features of this condition, especially the associated systemic 
      features, that may give some clues to its etiopathogenesis. In 15 of these 
      patients a single rectal ulcer was found, whereas in seven patients two ulcers 
      were present in each. Of the total 29 ulcers in these patients, 19 were located 
      on the anterior or anterolateral wall of the rectum and 10 were on the posterior 
      or posterolateral wall. The sigmoidoscopic appearance of the ulcer was quite 
      characteristic, yet a biopsy was considered essential to rule out other 
      pathologic processes. Histological features of the solitary rectal ulcer 
      comprised fibrous obliteration of the lamina propria with disorientation of the 
      muscularis mucosa and extension of muscle fibers into the lamina propria. Evident 
      rectal prolapse was present in only three patients. Recurrent oral ulcerations 
      occurred in four (18.2%) patients and erythema nodosum in one of them (4.5%). 
      Sacroiliitis was present in six of 19 (31%) patients studied radiologically, and 
      human leukocyte antigen (HLA)-B27 occurred in four of the 20 patients (20%) 
      tested for HLA class I antigens. All the four HLA-B27-positive patients had 
      associated sacroiliitis and showed good response to sulfasalazine. These 
      associations raise the possibility that solitary rectal ulcers may be a part of a 
      systemic disease or of several diseases with varied etiology.
FAU - Tandon, R K
AU  - Tandon RK
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi.
FAU - Atmakuri, S P
AU  - Atmakuri SP
FAU - Mehra, N K
AU  - Mehra NK
FAU - Malaviya, A N
AU  - Malaviya AN
FAU - Tandon, H D
AU  - Tandon HD
FAU - Chopra, P
AU  - Chopra P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Gastroenterol
JT  - Journal of clinical gastroenterology
JID - 7910017
RN  - 0 (HLA-B27 Antigen)
RN  - 3XC8GUZ6CB (Sulfasalazine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthritis/complications
MH  - Female
MH  - Fibrosis
MH  - HLA-B27 Antigen/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Rectal Diseases/*etiology
MH  - Sacroiliac Joint
MH  - Sigmoidoscopy
MH  - Sulfasalazine/therapeutic use
MH  - Ulcer/etiology/immunology/pathology
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - 10.1097/00004836-199006000-00010 [doi]
PST - ppublish
SO  - J Clin Gastroenterol. 1990 Jun;12(3):286-90. doi: 
      10.1097/00004836-199006000-00010.