PMID- 19731594
OWN - NLM
STAT- MEDLINE
DCOM- 20090929
LR  - 20090907
IS  - 1934-578X (Print)
IS  - 1555-9475 (Linking)
VI  - 4
IP  - 7
DP  - 2009 Jul
TI  - Synthesis of neolamellarin A, an inhibitor of hypoxia-inducible factor-1.
PG  - 925-6
AB  - Neolamellarin A, a metabolite isolated from the sponge Dendrilla nigra, was found 
      to inhibit hypoxia-inducible factor-1 (HIF-1) activation by 26% at 10 microM 
      concentration and inhibition of HIF-1 has become a major antitumor molecular 
      target. Herein the first synthesis of neolamellarin A is described. The synthetic 
      strategy features the condensation of vinylogous amide with aminomalonate to 
      construct the 3,4-bis(4-methoxyphenyl)-1H-pyrrole core and the subsequent 
      acylation and deprotection rendered the target compound in 18% over all yield.
FAU - Arafeh, Khaled M
AU  - Arafeh KM
AD  - Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 
      31261, Saudi Arabia.
FAU - Ullah, Nisar
AU  - Ullah N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nat Prod Commun
JT  - Natural product communications
JID - 101477873
RN  - 0 (Amides)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Pyrroles)
RN  - 0 (neolamellarin A)
SB  - IM
MH  - Acylation
MH  - Amides/chemistry
MH  - Animals
MH  - Hypoxia-Inducible Factor 1/*antagonists & inhibitors
MH  - Indicators and Reagents
MH  - Porifera/chemistry
MH  - Pyrroles
EDAT- 2009/09/08 06:00
MHDA- 2009/09/30 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2009/09/30 06:00 [medline]
PST - ppublish
SO  - Nat Prod Commun. 2009 Jul;4(7):925-6.