PMID- 19731625
OWN - NLM
STAT- MEDLINE
DCOM- 20090928
LR  - 20190622
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 649
DP  - 2009
TI  - Biomarkers in spondyloarthropathies.
PG  - 122-32
AB  - The study of biomarkers in spondyloarthropathy (SpA) has emerged to be a very 
      important field of research. This is particularly because the two commonly used 
      biomarkers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), 
      are of very low sensitivity and specificity. The second reason is, with advances 
      in the treatment of SpA by the very expensive tumor necrosis factor-alpha 
      (TNF-alpha) blockers, for cost-effectiveness, clinicians need to be much more 
      accurate in predicting disease progression, evaluating disease activity and 
      monitoring therapeutic efficacy. This review focuses on several biomarkers of 
      promise: matrix metalloproteinases 3 (MMP-3), Type II collagen neoepitope (C2C 
      and C1-2C), C-propeptide of Type II collagen (CPII), aggrecan 846 epitope, 
      macrophage colony stimulating factor (M-CSF), serum amyloid A (SAA) and 
      Interleukin-6 (IL-6). The results summarized in Table 1 call for a co-ordinated 
      effort for systematic studies of existing biomarkers and for search for new 
      candidates.
FAU - Chen, Chun-Hsiung
AU  - Chen CH
AD  - Institute of Clinical Medicine, National Yang-Ming University, Veterans General 
      Hospital-Taipei, Taipei, Taiwan.
FAU - Yu, David Tak Yan
AU  - Yu DT
FAU - Chou, Chung-Tei
AU  - Chou CT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Amyloid A Protein)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Biomarkers/*metabolism
MH  - Disease Progression
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Macrophage Colony-Stimulating Factor/metabolism
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Serum Amyloid A Protein/metabolism
MH  - Severity of Illness Index
MH  - Spondylarthropathies/*metabolism/physiopathology
MH  - Tissue Inhibitor of Metalloproteinases/metabolism
RF  - 62
EDAT- 2009/09/08 06:00
MHDA- 2009/09/29 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2009/09/29 06:00 [medline]
AID - 10.1007/978-1-4419-0298-6_9 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2009;649:122-32. doi: 10.1007/978-1-4419-0298-6_9.