PMID- 19731638
OWN - NLM
STAT- MEDLINE
DCOM- 20090928
LR  - 20201222
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 649
DP  - 2009
TI  - KIR genes and their role in spondyloarthropathies.
PG  - 286-99
AB  - Cellular activity of natural killer cells (NK cells) is defined by the balance 
      between activating and inhibitory signals coming from their receptors. With 
      respect to this response, killer immunoglobulin-like receptors (KIR) are unique 
      because of their diversity and capacity to recognize specific human leukocyte 
      antigen (HLA) class I allotypes. Up to the present few studies have 
      experimentally been developed concerning the role of KIR genes in 
      spondyloarthropathies (SpA) and its clear relationship with HLA-B27. However, the 
      role of the HLA-B27 heavy chain homodimers and their possible recognition by KIR 
      receptors in the pathogenesis of spondylarthritides has been studied. Moreover, 
      it has been suggested that NK cells and their receptors could play a role in 
      ankylosing spondylitis (AS) development. Several association studies based on a 
      model in which KIRs synergize with HLAs have also been published. This 
      interaction may generate compound genotypes which provide different levels of 
      activation or inhibition. Furthermore, some of these have been associated with 
      certain SpA, such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA).
FAU - Diaz-Pena, Roberto
AU  - Diaz-Pena R
AD  - Hospital Universitario Central de Asturias, Oviedo, Spain.
FAU - Blanco-Gelaz, Miguel Angel
AU  - Blanco-Gelaz MA
FAU - Lopez-Larrea, Carlos
AU  - Lopez-Larrea C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Alleles
MH  - HLA-B27 Antigen/genetics/immunology
MH  - Histocompatibility Antigens Class I/genetics/immunology
MH  - Humans
MH  - Ligands
MH  - Receptors, KIR/*genetics/immunology
MH  - *Spondylarthropathies/genetics/immunology
RF  - 78
EDAT- 2009/09/08 06:00
MHDA- 2009/09/29 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2009/09/29 06:00 [medline]
AID - 10.1007/978-1-4419-0298-6_22 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2009;649:286-99. doi: 10.1007/978-1-4419-0298-6_22.