PMID- 1973197
OWN - NLM
STAT- MEDLINE
DCOM- 19900813
LR  - 20151119
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 254
IP  - 1
DP  - 1990 Jul
TI  - Serotonergic modulation of rat pup ultrasonic vocal development: studies with 
      3,4-methylenedioxymethamphetamine.
PG  - 212-20
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) has previously been shown to destroy 
      serotonin terminals in the rat brain. Despite profound and prolonged loss of 
      serotonin innervation, long-term behavioral effects of MDMA have not previously 
      been reported. In this study, we monitored the short- and long-term effects of 
      MDMA administration on the ultrasonic isolation call of the rat pup. At 30 to 60 
      min after a single dose of MDMA (0.5-10.0 mg/kg), isolation calls decreased as 
      much as 90%, with a rebound increase in calling noted 10 to 25 h following 
      administration of the highest dose. Repeated administration of 10 mg/kg MDMA 
      (once or twice daily on postnatal days 1-4) resulted in a lasting, dose-dependent 
      decrease in ultrasonic vocalization monitored on days 6, 9, 12 and 15. Concurrent 
      measures of locomotor behavior, geotaxis and weight gain were not altered 
      subsequent to repeated MDMA treatment. Both serotonin content and serotonin 
      terminals (assessed by [3H]paroxetine binding) in cortex were reduced by repeated 
      MDMA treatment, whereas concentrations of catecholamines and their metabolites 
      were unaltered. Repeated prenatal MDMA exposure did not affect postnatal rates of 
      calling or the biochemical markers of serotonin in cortex. Pups lesioned with 
      MDMA postnatally showed not only long-term behavioral and biochemical changes but 
      also altered responsiveness to the serotonin 1B agonist 
      1-[3-(trifluromethyl)phenyl]piperazine. Taken together, these studies indicate 
      that serotonergic lesions in a sensitive phase of development can have long-term 
      selective effects on the rat pup ultrasonic isolation call, a behavior critical 
      for mother-infant affiliation.
FAU - Winslow, J T
AU  - Winslow JT
AD  - National Institute of Mental Health, Poolesville, Maryland.
FAU - Insel, T R
AU  - Insel TR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Amphetamines)
RN  - 0 (Piperazines)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 25R3ONU51C (1-(3-trifluoromethylphenyl)piperazine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Piperazines/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/*drug effects
MH  - Tetrahydronaphthalenes/pharmacology
MH  - Ultrasonics
MH  - Vocalization, Animal/*drug effects
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1990 Jul;254(1):212-20.