PMID- 19732962
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20131121
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 216
IP  - 1-2
DP  - 2009 Nov 30
TI  - Role of dopamine in the physiology of T-cells and dendritic cells.
PG  - 8-19
LID - 10.1016/j.jneuroim.2009.07.018 [doi]
AB  - Dendritic cells (DCs) are responsible for priming T-cells and for promoting their 
      differentiation from naive T-cells into appropriate effector cells. Because of 
      their fundamental roles in controlling immunity, DCs and T-cells require tight 
      regulatory mechanisms. Several studies have shown that dopamine, not only mediate 
      interactions into the nervous system, but can also contribute to the modulation 
      of immunity. Here, we review the emerging role of this neurotransmitter as a 
      regulator of DC and T-cell physiology and, in turn, immune response. Moreover, we 
      discuss how alterations in the dopamine-mediated immune regulatory mechanisms 
      could contribute to the onset of immune-related disorders.
FAU - Pacheco, Rodrigo
AU  - Pacheco R
AD  - Fundacion Ciencia para la Vida, Santiago, Chile. rodrigo.pacheco@bionova.cl
FAU - Prado, Carolina E
AU  - Prado CE
FAU - Barrientos, Magaly J
AU  - Barrientos MJ
FAU - Bernales, Sebastian
AU  - Bernales S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090904
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/physiology
MH  - Autoimmune Diseases of the Nervous System/*physiopathology
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/immunology/*metabolism
MH  - Dopamine/*metabolism
MH  - Humans
MH  - Immunomodulation/physiology
MH  - Neuroimmunomodulation/*physiology
MH  - Signal Transduction/immunology
MH  - T-Lymphocytes/immunology/*metabolism
RF  - 130
EDAT- 2009/09/08 06:00
MHDA- 2010/01/12 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/04/17 00:00 [received]
PHST- 2009/07/22 00:00 [revised]
PHST- 2009/07/28 00:00 [accepted]
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
AID - S0165-5728(09)00299-9 [pii]
AID - 10.1016/j.jneuroim.2009.07.018 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2009 Nov 30;216(1-2):8-19. doi: 10.1016/j.jneuroim.2009.07.018. 
      Epub 2009 Sep 4.