PMID- 19733629
OWN - NLM
STAT- MEDLINE
DCOM- 20100114
LR  - 20161125
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 465
IP  - 1
DP  - 2009 Nov 6
TI  - Amelioration of cognitive ability in senescence-accelerated mouse prone 8 (SAMP8) 
      by intra-bone marrow-bone marrow transplantation.
PG  - 36-40
LID - 10.1016/j.neulet.2009.09.001 [doi]
AB  - Bone marrow cells (BMCs) can increase the number of activated microglias, which 
      play a central role in the inflammatory response in Alzheimer's disease (AD). 
      Senescence-accelerated mouse (SAM) prone 8 (SAMP8) are widely used in various 
      experiments because of cognitive deficits observed with age. In the present 
      study, 4-month-old SAMP8 were reconstituted with BMCs of C57BL/6 mice by 
      intra-bone marrow-bone marrow transplantation (IBM-BMT), which can reconstitute 
      both donor-derived hemopoietic stem cells and mesenchymal stem cells. Three 
      months after IBM-BMT, the impairment of spatial memory in SAMP8 was found to be 
      ameliorated after analyzing the results of the water maze test. Although 
      IL-1beta, IL-6 and iNOS increased and TGF-beta decreased in 7M SAMP8, IL-1beta, 
      IL-6 and iNOS decreased while TGF-beta increased after IBM-BMT by RT-PCR. 
      Moreover, oxidative stress-related heme oxygenase-1 (HO-1) increased in 7M SAMP8, 
      but significantly decreased after IBM-BMT. In conclusion, this is the first 
      report suggesting that the impaired cognitive ability of SAMP8 is ameliorated by 
      IBM-BMT. It seems likely that decreases in IL-1beta, IL-6, iNOS and HO-1 are a 
      result of the development of donor-derived BMCs.
FAU - Li, Ming
AU  - Li M
AD  - First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, 
      Japan.
FAU - Inaba, Muneo
AU  - Inaba M
FAU - Guo, Kequan
AU  - Guo K
FAU - Abraham, Nader G
AU  - Abraham NG
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090905
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nos2 protein, mouse)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Bone Marrow Transplantation/*methods
MH  - Brain/*metabolism
MH  - Cognition Disorders/*metabolism/*surgery
MH  - Heme Oxygenase-1/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/metabolism
MH  - Leukocytes, Mononuclear/metabolism
MH  - Male
MH  - Maze Learning
MH  - Memory Disorders/metabolism/surgery
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Transforming Growth Factor beta/metabolism
EDAT- 2009/09/08 06:00
MHDA- 2010/01/15 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/05/25 00:00 [received]
PHST- 2009/08/24 00:00 [revised]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2010/01/15 06:00 [medline]
AID - S0304-3940(09)01199-9 [pii]
AID - 10.1016/j.neulet.2009.09.001 [doi]
PST - ppublish
SO  - Neurosci Lett. 2009 Nov 6;465(1):36-40. doi: 10.1016/j.neulet.2009.09.001. Epub 
      2009 Sep 5.