PMID- 19733632
OWN - NLM
STAT- MEDLINE
DCOM- 20100219
LR  - 20091116
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 164
IP  - 4
DP  - 2009 Dec 29
TI  - Direct projections from the sacral spinal cord to the medial preoptic area in cat 
      and guinea pig.
PG  - 1732-43
LID - 10.1016/j.neuroscience.2009.08.062 [doi]
AB  - The medial preoptic area (MPO) plays an important role in many behavioral, 
      autonomic and endocrine functions, including micturition and genital responses. 
      Although afferents of the MPO have been studied extensively, it is unknown 
      whether direct lumbosacral-MPO projections exist that could convey afferent 
      information from the pelvic organs. We hypothesized that, if such direct 
      projections exist, MPO projecting cells would be located in the lateral part of 
      the sacral cord, where primary afferents from pelvic and pudendal nerves 
      terminate. We used retro- and anterograde tracing techniques in cat and guinea 
      pig to study this. In cats, injections in the MPO resulted in labeled cells 
      throughout the spinal cord, but with the highest density in the S1-S2 segments. 
      In guinea pigs, labeled cells were found exclusively in the S1-S3 segments after 
      MPO injections. Labeled cells in the sacral segments were not located in the 
      lateral parts of the gray matter, but were found in the medial laminae VI-VII and 
      dorsal lamina VIII in cats, and mainly in lamina X in guinea pigs. Anterograde 
      tracing results after injections in the sacral cord in cats or guinea pigs showed 
      labeled fibers in the MPO, just ventral to the anterior commissure. The central 
      location of the cells of origin within the sacral cord, together with the 
      termination pattern of the spino-MPO projections, strongly suggest a role for the 
      spino-MPO pathway in the sensory relay of pelvic viscera, important for 
      micturition and genital responses.
FAU - Klop, E M
AU  - Klop EM
AD  - Section of Anatomy, Department of Neuroscience, University Medical Center 
      Groningen, University of Groningen, PO Box 196, 9700 AD Groningen, The 
      Netherlands. e.m.klop@med.umcg.nl
FAU - Kuipers, R
AU  - Kuipers R
FAU - Mouton, L J
AU  - Mouton LJ
LA  - eng
PT  - Journal Article
DEP - 20090904
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
SB  - IM
MH  - Animals
MH  - Cats
MH  - Female
MH  - Guinea Pigs
MH  - Male
MH  - Preoptic Area/*physiology
MH  - Spinal Cord/*physiology
EDAT- 2009/09/08 06:00
MHDA- 2010/02/20 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/01/19 00:00 [received]
PHST- 2009/08/26 00:00 [revised]
PHST- 2009/08/27 00:00 [accepted]
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2010/02/20 06:00 [medline]
AID - S0306-4522(09)01420-1 [pii]
AID - 10.1016/j.neuroscience.2009.08.062 [doi]
PST - ppublish
SO  - Neuroscience. 2009 Dec 29;164(4):1732-43. doi: 
      10.1016/j.neuroscience.2009.08.062. Epub 2009 Sep 4.