PMID- 19734627
OWN - NLM
STAT- MEDLINE
DCOM- 20091207
LR  - 20220331
IS  - 1590-8577 (Electronic)
IS  - 1590-8577 (Linking)
VI  - 10
IP  - 5
DP  - 2009 Sep 4
TI  - Pancreatic neuroendocrine tumors among patients with intraductal papillary 
      mucinous neoplasms: real association or just a coincidence?
PG  - 515-7
AB  - CONTEXT: Intraductal papillary mucinous neoplasms (IPMNs) are being recognized 
      with increased frequency and are the most common indication of pancreatic surgery 
      at specialized centers. Many IPMN patients are found to have non-IPMN related 
      pancreatic tumors like pancreatic neuroendocrine tumors (PNTs). OBJECTIVE: To 
      study the prevalence of PNTs among patients with IPMN. METHODS: Patients who 
      underwent surgical resection for IPMN were retrospectively reviewed for presence 
      of histologically proven PNTs. The PNTs were evaluated for the patient 
      demographics, imaging characteristics, histology, and surgical staging. RESULTS: 
      Between January 2002 and October 2007, 104 patients underwent surgery for 
      pancreatic IPMN. Among these, 4 patients (3.8%) were diagnosed with concomitant 
      PNTs (1 male, 3 females; median age 72 years). Three patients had branch duct 
      type-IPMN (cyst size: 19 mm, 15 mm and 27 mm), and one had main duct type-IPMN. 
      Only one branch duct IPMN had adenocarcinoma, other three had low 
      grade/borderline dysplasia. The median size of PNT was 10 mm (range 8-16 mm) and 
      all were missed on the cross sectional imaging. Three patients were recognized by 
      endoscopic ultrasound (EUS) and the fine needle aspiration confirmed the 
      diagnosis in 1/3. Only one patient had metastatic PNT to lymph node, the other 
      three were low grade lesions. CONCLUSION: IPMN and PNT can coexist. The 
      prevalence of PNT among IPMN patients is low (3.8%). Our study is limited by 
      small sample size. Large studies with large number of patients are needed to 
      further explore this association.
FAU - Gill, Kanwar Rupinder S
AU  - Gill KR
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL 32224, 
      USA.
FAU - Scimeca, Daniela
AU  - Scimeca D
FAU - Stauffer, John
AU  - Stauffer J
FAU - Krishna, Murli
AU  - Krishna M
FAU - Woodward, Timothy A
AU  - Woodward TA
FAU - Jamil, Laith H
AU  - Jamil LH
FAU - Wallace, Michael B
AU  - Wallace MB
FAU - Nguyen, Justin H
AU  - Nguyen JH
FAU - Raimondo, Massimo
AU  - Raimondo M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090904
PL  - England
TA  - JOP
JT  - JOP : Journal of the pancreas
JID - 101091810
SB  - IM
MH  - Adenocarcinoma, Mucinous/diagnostic imaging/*epidemiology/pathology
MH  - Aged
MH  - Carcinoma, Pancreatic Ductal/diagnostic imaging/*epidemiology/pathology
MH  - Carcinoma, Papillary/diagnostic imaging/*epidemiology/pathology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Neoplasms, Multiple Primary/diagnostic imaging/epidemiology/pathology
MH  - Neuroendocrine Tumors/diagnostic imaging/*epidemiology/pathology
MH  - Pancreatic Neoplasms/diagnostic imaging/*epidemiology/pathology
MH  - Radiography
MH  - Retrospective Studies
EDAT- 2009/09/08 06:00
MHDA- 2009/12/16 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - v10i05a07 [pii]
PST - epublish
SO  - JOP. 2009 Sep 4;10(5):515-7.