PMID- 19736602
OWN - NLM
STAT- MEDLINE
DCOM- 20091127
LR  - 20231105
IS  - 2000-1967 (Electronic)
IS  - 0300-9734 (Print)
IS  - 0300-9734 (Linking)
VI  - 114
IP  - 3
DP  - 2009
TI  - Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats.
PG  - 136-9
LID - 10.1080/03009730903174321 [doi]
AB  - BACKGROUND: Renal failure is an increasingly common condition with limited 
      treatment options that is causing a major financial and emotional burden on the 
      community. Andrographis paniculata is the plant used in Ayurveda for several 
      remedies. Scientific evidence suggests its versatile biological functions that 
      support its traditional use in the Orient. The plant is claimed to possess 
      immunological, antibacterial, anti-inflammatory, antithrombotic, and 
      hepatoprotective properties. But, to date, there is no study demonstrating the 
      protective effect of A. paniculata on gentamicin-induced renal failure. The 
      present study aims to highlight the first ever reported, antirenal failure 
      activity of A. paniculata. METHODS: Male Wistar albino rats were divided into 
      three groups: normal control, gentamicin control, and aqueous extract of A. 
      paniculata (200 mg/kg, per oral (p.o.))-treated. The nephrotoxic model was 
      induced by gentamicin (80 mg/kg, intraperitoeal (i.p.)). Blood samples were 
      examined for serum creatinine, serum urea, and blood urea nitrogen after the 10 
      days of treatment. RESULTS: A gentamicin-induced nephrotoxic animal model was 
      successfully prepared. Aqueous extract of A. paniculata attenuated the 
      gentamicin-induced increase in serum creatinine, serum urea, and blood urea 
      nitrogen levels by 176.92%, 106.27%, and 202.90%, respectively. CONCLUSION: The 
      present study reports that the aqueous extract (whole plant) of A. paniculata 
      (Burm. f.) Nees exhibits a significant renoprotective effect in 
      gentamicin-induced nephrotoxicity in male Wistar albino rats.
FAU - Singh, Pratibha
AU  - Singh P
AD  - Department of Chemistry, Dayalbagh Educational Institute (Deemed University), 
      Agra, India.
FAU - Srivastava, Man Mohan
AU  - Srivastava MM
FAU - Khemani, Lakhu Dev
AU  - Khemani LD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Ups J Med Sci
JT  - Upsala journal of medical sciences
JID - 0332203
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Gentamicins)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Andrographis/*chemistry
MH  - Animals
MH  - Anti-Bacterial Agents/toxicity
MH  - Blood Urea Nitrogen
MH  - Gentamicins/toxicity
MH  - Kidney/*drug effects
MH  - Male
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Renal Insufficiency/chemically induced
PMC - PMC2852765
EDAT- 2009/09/09 06:00
MHDA- 2009/12/16 06:00
PMCR- 2009/09/01
CRDT- 2009/09/09 06:00
PHST- 2009/09/09 06:00 [entrez]
PHST- 2009/09/09 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2009/09/01 00:00 [pmc-release]
AID - 914548447 [pii]
AID - UPS_A_417605_O [pii]
AID - 10.1080/03009730903174321 [doi]
PST - ppublish
SO  - Ups J Med Sci. 2009;114(3):136-9. doi: 10.1080/03009730903174321.