PMID- 19737610
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20211020
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 32
IP  - 2
DP  - 2010 Mar-Apr
TI  - Glucose and corticosterone changes in developing and adult rats following 
      exposure to (+/-)-3,4-methylendioxymethamphetamine or 
      5-methoxydiisopropyltryptamine.
PG  - 152-7
LID - 10.1016/j.ntt.2009.08.012 [doi]
AB  - The use of the club drugs 3,4-methylenedioxymethamphetamine (MDMA) and 
      5-methoxy-n,n-diisopropyltryptamine (Foxy) is of growing concern, especially as 
      many of the effects, particularly during development, are unknown. The effects of 
      these drugs upon homeostasis may be important since both are known to stimulate 
      the hypothalamic-pituitary-adrenal axis. The purpose of this experiment was to 
      examine alterations in rats in corticosterone and glucose following an acute 
      exposure to these drugs at different stages of development: preweaning, juvenile, 
      and adulthood. Both MDMA and Foxy increased corticosterone levels significantly 
      at all ages examined, while glucose was elevated at all stages except at the 
      juvenile time point (postnatal day 28). For both measures, there were no 
      differences between the sexes with either drug. The data indicate that an acute 
      exposure to these drugs alters CORT and glucose levels, raising the possibility 
      that these changes may have effects on behavioral and cognitive function, as we 
      and others have previously demonstrated.
CI  - Copyright (c) 2009 Elsevier Inc. All rights reserved.
FAU - Graham, Devon L
AU  - Graham DL
AD  - Division of Neurology, Cincinnati Children's Research Foundation, & Department of 
      Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 
      45229-3039, USA.
FAU - Herring, Nicole R
AU  - Herring NR
FAU - Schaefer, Tori L
AU  - Schaefer TL
FAU - Vorhees, Charles V
AU  - Vorhees CV
FAU - Williams, Michael T
AU  - Williams MT
LA  - eng
GR  - T32 ES007051-33/ES/NIEHS NIH HHS/United States
GR  - DA006733/DA/NIDA NIH HHS/United States
GR  - T32 ES007051/ES/NIEHS NIH HHS/United States
GR  - ES07051/ES/NIEHS NIH HHS/United States
GR  - R01 DA006733/DA/NIDA NIH HHS/United States
GR  - R01 DA006733-17/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090906
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Serotonin Agents)
RN  - 12D06G8W8E (5-methoxy-N,N-diisopropyltryptamine)
RN  - 3VMW6141KC (5-Methoxytryptamine)
RN  - IY9XDZ35W2 (Glucose)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 5-Methoxytryptamine/*analogs & derivatives/toxicity
MH  - Age Factors
MH  - Aging/physiology
MH  - Animals
MH  - Corticosterone/*blood/metabolism
MH  - Female
MH  - Glucose/*metabolism
MH  - Hypothalamo-Hypophyseal System/*drug effects/growth & development/physiopathology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Pituitary-Adrenal System/*drug effects/growth & development/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin Agents/toxicity
MH  - Up-Regulation/drug effects/physiology
PMC - PMC2839063
MID - NIHMS150349
EDAT- 2009/09/10 06:00
MHDA- 2010/06/16 06:00
PMCR- 2011/03/01
CRDT- 2009/09/10 06:00
PHST- 2009/03/27 00:00 [received]
PHST- 2009/08/21 00:00 [revised]
PHST- 2009/08/29 00:00 [accepted]
PHST- 2009/09/10 06:00 [entrez]
PHST- 2009/09/10 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - S0892-0362(09)00171-8 [pii]
AID - 10.1016/j.ntt.2009.08.012 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2010 Mar-Apr;32(2):152-7. doi: 10.1016/j.ntt.2009.08.012. 
      Epub 2009 Sep 6.