PMID- 19738329
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20200930
IS  - 1523-7834 (Print)
IS  - 1523-7834 (Linking)
VI  - 35
IP  - 3
DP  - 2009
TI  - A Cryptic t(1;21;8)(p36;q22;q22) in a Case of Acute Myeloid Leukemia with 
      Maturation.
PG  - 88-92
AB  - The t(8;21)/RUNX1-RUNX1T1 is found in ~5 percent of cases of acute myeloid 
      leukemia (AML) and in 10 percent of the prior AML with maturation (M2) category 
      of the French-American-British (FAB) classification. While AML with t(8;21) is 
      considered a distinct entity with a favorable prognosis, the clinical consequence 
      of variant translocations is less well defined. In this report we described a 45 
      year-old male patient having a diagnosis of AML-M2 with morphologic and 
      immunophenotypic features suggestive of t(8;21). However, the initial karyotypic 
      analysis revealed an apparently balanced translocation between 1p36 and 8q22. 
      Further fluorescence in situ hybridization (FISH) studies using the AML1/ETO and 
      the p58 probes from Abbott Molecular, demonstrated a three-way translocation 
      between chromosomes 1, 21, and 8, with single fusion of RUNX1-RUNX1T1 on the 
      derivative chromosome 8 [t(1;21;8)(p36.1;q22;q22)]. The patient was in complete 
      remission after induction therapy followed by consolidation. This report 
      demonstrates the importance of FISH studies for detection of cryptic specific 
      chromosome rearrangements that may have prognostic significance.
FAU - Tirado, Carlos A
AU  - Tirado CA
AD  - Laboratory of Cytogenetics, UT Southwestern Medical Center, Dallas, TX.
FAU - Chena, Weina
AU  - Chena W
FAU - Valdez, Federico J
AU  - Valdez FJ
FAU - Henderson, Samuel
AU  - Henderson S
FAU - Smart, Ruth L
AU  - Smart RL
FAU - Doolittle, Jeff
AU  - Doolittle J
FAU - Garcia, Rolando
AU  - Garcia R
FAU - Patel, Sangeeta
AU  - Patel S
FAU - Holdridge, Scott
AU  - Holdridge S
FAU - Chastain, Candace
AU  - Chastain C
FAU - Auchus, Mary
AU  - Auchus M
FAU - Collins, Robert H
AU  - Collins RH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Assoc Genet Technol
JT  - Journal of the Association of Genetic Technologists
JID - 9807282
EDAT- 2009/09/10 06:00
MHDA- 2009/09/10 06:01
CRDT- 2009/09/10 06:00
PHST- 2009/09/10 06:00 [entrez]
PHST- 2009/09/10 06:00 [pubmed]
PHST- 2009/09/10 06:01 [medline]
PST - ppublish
SO  - J Assoc Genet Technol. 2009;35(3):88-92.