PMID- 19738442
OWN - NLM
STAT- MEDLINE
DCOM- 20100104
LR  - 20190516
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Linking)
VI  - 5
IP  - 7
DP  - 2009 Oct
TI  - The complexity in regulation of MEF2D by chaperone-mediated autophagy.
PG  - 1073-4
AB  - Chaperone-mediated autophagy (CMA) targets specific cytoplasmic proteins for 
      degradation by lysosomes and has been implicated to play a role in 
      neurodegeneration. Our recent studies identify neuronal survival factor MEF2D as 
      a direct substrate of CMA and show that dysregulation of this process may 
      contribute to the pathogenesis of Parkinson disease. One interesting finding 
      presented in our study is the apparent loss of DNA binding capacity by the 
      accumulated MEF2D following inhibition of CMA. The possibilities and implication 
      of this finding are discussed.
FAU - Yang, Qian
AU  - Yang Q
AD  - Department of Pharmacology and Neurology, Emory University School of Medicine, 
      Atlanta, GA 30322, USA.
FAU - Mao, Zixu
AU  - Mao Z
LA  - eng
GR  - AG023695/AG/NIA NIH HHS/United States
GR  - ES015317/ES/NIEHS NIH HHS/United States
GR  - NS048254/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091015
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (MADS Domain Proteins)
RN  - 0 (MEF2 Transcription Factors)
RN  - 0 (MEF2D protein, human)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Myogenic Regulatory Factors)
SB  - IM
MH  - Autophagy/*physiology
MH  - Humans
MH  - MADS Domain Proteins/*metabolism
MH  - MEF2 Transcription Factors
MH  - Molecular Chaperones/*metabolism
MH  - Myogenic Regulatory Factors/*metabolism
MH  - Neurons/metabolism
MH  - Parkinson Disease/physiopathology
EDAT- 2009/09/10 06:00
MHDA- 2010/01/05 06:00
CRDT- 2009/09/10 06:00
PHST- 2009/09/10 06:00 [entrez]
PHST- 2009/09/10 06:00 [pubmed]
PHST- 2010/01/05 06:00 [medline]
AID - 9824 [pii]
AID - 10.4161/auto.5.7.9824 [doi]
PST - ppublish
SO  - Autophagy. 2009 Oct;5(7):1073-4. doi: 10.4161/auto.5.7.9824. Epub 2009 Oct 15.