PMID- 19740260
OWN - NLM
STAT- MEDLINE
DCOM- 20091231
LR  - 20151119
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 14
IP  - 7
DP  - 2009 Sep
TI  - Correlation between serum biomarkers and BODE index in patients with stable COPD.
PG  - 999-1004
LID - 10.1111/j.1440-1843.2009.01608.x [doi]
AB  - BACKGROUND AND OBJECTIVE: The BODE index, based on BMI, obstructive ventilatory 
      impairment, dyspnoea scale and exercise capacity, has been used to evaluate the 
      severity of patients with COPD. However, the correlations between serum 
      biomarkers and the BODE index in patients with stable COPD are not widely 
      studied. This study evaluated potential serum biomarkers for their ability to 
      identify smokers with COPD and reflect disease severity. METHODS: A comparative 
      study was conducted of 100 clinically stable COPD patients and 50 matched healthy 
      smokers and the difference in levels of biomarkers between the COPD patients and 
      healthy smokers was measured. Serum inflammatory mediators measured were 
      growth-related oncogene-alpha (GRO-alpha), IL-8, tumour necrosis factor-alpha 
      (TNF-alpha), matrix metalloproteinase-9 (MMP-9) and monocyte chemoattractant 
      protein-1 (MCP-1). Variables included age, pack-years, current or ex-smoker 
      status, inhaler or oral steroid use and BODE index components, including airflow 
      obstruction, the distance walked in 6MWD, modified Medical Research Council 
      (MMRC) dyspnoea scale and BMI. The association between serum biomarkers and the 
      components of the BODE index was assessed in the COPD patients. RESULTS: The 
      level of serum MCP-1 was significantly different between the COPD group and the 
      healthy smoker group (P = 0.003). Significant results in univariate and 
      multivariate analysis of the association between biomarkers and BODE components 
      were: serum MCP-1 correlated with FEV(1)% and 6MWD; serum IL-8 and GRO-alpha 
      correlated with steroid use; serum TNF-alpha correlated with steroid use and 
      FEV(1)%; and serum MMP-9 correlated with MMRC dyspnoea scale. CONCLUSIONS: No 
      single specific serum inflammatory mediator was completely correlated with BODE 
      variable parameters in patients with stable COPD. Serum MCP-1 may be an important 
      biomarker for identifying COPD subjects from healthy smokers and classifying COPD 
      severity.
FAU - Liu, Shih-Feng
AU  - Liu SF
AD  - Division of Pulmonary, Department of Internal Medicine, Chang Gung Memorial 
      Hospital- Kaohsiung Medical Center, Kaohsiung Hsien, Taiwan.
FAU - Chin, Chien-Hung
AU  - Chin CH
FAU - Wang, Chin-Chou
AU  - Wang CC
FAU - Lin, Meng-Chih
AU  - Lin MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - *Body Mass Index
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Chemokine CXCL1/blood
MH  - Dyspnea/*physiopathology
MH  - Exercise Tolerance/*physiology
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Interleukin-8/blood
MH  - Lung/*physiopathology
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/blood/*diagnosis/physiopathology
MH  - *Severity of Illness Index
MH  - Smoking/blood/physiopathology
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2009/09/11 06:00
MHDA- 2010/01/01 06:00
CRDT- 2009/09/11 06:00
PHST- 2009/09/11 06:00 [entrez]
PHST- 2009/09/11 06:00 [pubmed]
PHST- 2010/01/01 06:00 [medline]
AID - RES1608 [pii]
AID - 10.1111/j.1440-1843.2009.01608.x [doi]
PST - ppublish
SO  - Respirology. 2009 Sep;14(7):999-1004. doi: 10.1111/j.1440-1843.2009.01608.x.