PMID- 19740315
OWN - NLM
STAT- MEDLINE
DCOM- 20100125
LR  - 20220331
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 128
IP  - 1 Suppl
DP  - 2009 Sep
TI  - Balance between early life tolerance and sensitization in allergy: dependence on 
      the timing and intensity of prenatal and postnatal allergen exposure of the 
      mother.
PG  - e541-50
LID - 10.1111/j.1365-2567.2008.03028.x [doi]
AB  - Allergens can be maternally transferred to the fetus or neonate, though it is 
      uncertain how this initial allergen exposure may impact the development of 
      allergy responses. To evaluate the roles of timing and level of maternal allergen 
      exposure in the early life sensitization of progeny, female BALB/c mice were 
      given ovalbumin (OVA) orally during pregnancy, lactation or weekly at each stage 
      to investigate the immunoglobulin E (IgE) antibody production and cellular 
      responsiveness of their offspring. Exposure to OVA during pregnancy was also 
      evaluated in OVA-specific T-cell receptor (TCR) transgenic (DO11.10) mice. The 
      effect of prenatal antigen exposure on offspring sensitization was dependent on 
      antigen intake, with low-dose OVA inducing tolerance followed by neonatal 
      immunization that was sustained even when pups were immunized when 3 weeks old. 
      These offspring received high levels of transforming growth factor-beta via 
      breastfeeding. High-dose exposure during the first week of pregnancy or perinatal 
      period induced transient inhibition of IgE production following neonatal 
      immunization; although for later immunization IgE production was enhanced in 
      these offspring. Postnatal maternal antigen exposure provided OVA transference 
      via breastfeeding, which consequently induced increased offspring susceptibility 
      to IgE antibody production according to week post-birth. The effect of low-dose 
      maternal exposure during pregnancy was further evaluated using OVA transgenic TCR 
      dams as a model. These progeny presented pronounced entry of CD4(+) T cells into 
      the S phase of the cell cycle with a skewed T helper type 2 response early in 
      life, revealing the occurrence of allergen priming in utero. The balance between 
      tolerance and sensitization depended on the amount and timing of maternal 
      allergen intake during pregnancy.
FAU - Fusaro, Ana Elisa
AU  - Fusaro AE
AD  - Laboratory of Dermatology and Immunodeficiencies, School of Medicine, University 
      of Sao Paulo, Sao Paulo, Brazil.
FAU - de Brito, Cyro Alves
AU  - de Brito CA
FAU - Taniguchi, Eliana Futata
AU  - Taniguchi EF
FAU - Muniz, Bruno Pacola
AU  - Muniz BP
FAU - Victor, Jefferson Russo
AU  - Victor JR
FAU - Orii, Noemia Mie
AU  - Orii NM
FAU - Duarte, Alberto Jose da Silva
AU  - Duarte AJ
FAU - Sato, Maria Notomi
AU  - Sato MN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081218
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Transforming Growth Factor beta)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Administration, Oral
MH  - Allergens/*immunology
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cytokines/biosynthesis/*immunology
MH  - Female
MH  - Hypersensitivity/*immunology
MH  - *Immune Tolerance
MH  - Immunoglobulin E/blood
MH  - Male
MH  - *Maternal Exposure
MH  - Maternal-Fetal Exchange/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Transgenic
MH  - Ovalbumin/immunology
MH  - Pregnancy
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - Transforming Growth Factor beta/metabolism
PMC - PMC2753947
EDAT- 2009/09/25 06:00
MHDA- 2010/01/26 06:00
PMCR- 2010/09/01
CRDT- 2009/09/11 06:00
PHST- 2009/09/11 06:00 [entrez]
PHST- 2009/09/25 06:00 [pubmed]
PHST- 2010/01/26 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - IMM3028 [pii]
AID - 10.1111/j.1365-2567.2008.03028.x [doi]
PST - ppublish
SO  - Immunology. 2009 Sep;128(1 Suppl):e541-50. doi: 10.1111/j.1365-2567.2008.03028.x. 
      Epub 2008 Dec 18.