PMID- 19740503
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20211020
IS  - 1878-3503 (Electronic)
IS  - 0035-9203 (Print)
IS  - 0035-9203 (Linking)
VI  - 103
IP  - 12
DP  - 2009 Dec
TI  - Mode of action and choice of antimalarial drugs for intermittent preventive 
      treatment in infants.
PG  - 1199-201
LID - 10.1016/j.trstmh.2009.06.007 [doi]
AB  - Intermittent preventive treatment in infants (IPTi) is an effective and safe 
      malaria control strategy. However, it remains unclear what antimalarials should 
      be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer 
      an effective drug for IPTi. Work recently conducted in Tanzania, combined with 
      the findings of previous studies, indicates that IPTi is essentially intermittent 
      chemoprophylaxis; consequently, long-acting antimalarials that provide a long 
      period of post-treatment prophylaxis will be the most effective alternative to 
      SP. However, because of concerns about development of drug resistance, new 
      combinations of long-acting drugs are urgently needed.
FAU - Cairns, Matthew
AU  - Cairns M
AD  - London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, 
      UK. matthew.cairns@lshtm.ac.uk
FAU - Gosling, Roly
AU  - Gosling R
FAU - Gesase, Samwel
AU  - Gesase S
FAU - Mosha, Jacklin
AU  - Mosha J
FAU - Greenwood, Brian
AU  - Greenwood B
FAU - Chandramohan, Daniel
AU  - Chandramohan D
LA  - eng
GR  - G0700837/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090908
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
RN  - 0 (Antimalarials)
RN  - 0 (Drug Combinations)
RN  - 220236ED28 (Amodiaquine)
RN  - 37338-39-9 (fanasil, pyrimethamine drug combination)
RN  - 88463U4SM5 (Sulfadoxine)
RN  - TML814419R (Mefloquine)
RN  - Z3614QOX8W (Pyrimethamine)
SB  - IM
MH  - Amodiaquine/*pharmacology
MH  - Antimalarials/*pharmacology
MH  - Clinical Trials as Topic
MH  - Drug Combinations
MH  - Drug Resistance
MH  - Female
MH  - Humans
MH  - Infant
MH  - Malaria/*prevention & control
MH  - Male
MH  - Mefloquine/*pharmacology
MH  - Pyrimethamine/*pharmacology
MH  - Sulfadoxine/*pharmacology
PMC - PMC3787296
MID - EMS54606
OID - NLM: EMS54606
EDAT- 2009/09/11 06:00
MHDA- 2010/12/14 06:00
PMCR- 2013/10/01
CRDT- 2009/09/11 06:00
PHST- 2009/05/26 00:00 [received]
PHST- 2009/06/04 00:00 [revised]
PHST- 2009/06/04 00:00 [accepted]
PHST- 2009/09/11 06:00 [entrez]
PHST- 2009/09/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - S0035-9203(09)00201-6 [pii]
AID - 10.1016/j.trstmh.2009.06.007 [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 2009 Dec;103(12):1199-201. doi: 
      10.1016/j.trstmh.2009.06.007. Epub 2009 Sep 8.