PMID- 19742184
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20231103
IS  - 0019-5545 (Print)
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 50
IP  - 3
DP  - 2008 Jul
TI  - Analysis of the role of human leukocyte antigen class-I genes to understand the 
      etiopathology of schizophrenia.
PG  - 166-70
LID - 10.4103/0019-5545.43625 [doi]
AB  - BACKGROUND: Schizophrenia is the paradigmatic illness of psychiatry. The 
      involvement of immunological and immunopathological mechanisms in the 
      etiopathogenesis of schizophrenia has been a matter of research, with recently 
      increasing effort. AIMS: In this study, we investigated the incidence of human 
      leukocyte antigen (HLA) Class I antigens to understand the role of HLA genes in 
      schizophrenia. MATERIALS AND METHODS: India born schizophrenic patients in and 
      around Siliguri who attended outpatient department (OPD) of Department of 
      Psychiatry, North Bengal Medical College and Hospital were considered for the 
      present study. After the longitudinal follow up, 50 patients were enrolled for 
      the study. The same number of age, sex and ethnically matched healthy subjects 
      were considered as control. Low resolution polymerase chain reaction-sequence 
      specific primer method was applied for typing the HLA antigens. STATISTICS: The 
      phenotype frequencies were calculated by direct count. chi(2) test was done to 
      compare the frequency of each antigen among the patients and control group and it 
      was followed by Fisher's exact test. Relative risk was estimated by using 
      Haldane's method. RESULTS: The result showed that some of the HLA antigens are 
      associated with the schizophrenia and significant increase were observed for HLA 
      A*03 antigen along with the significant decrease for HLA A*25, A*31 and HLA B*51. 
      CONCLUSIONS: The study provides the evidence for the possible existence of 
      susceptibility locus for schizophrenia within the HLA region. This preliminary 
      observation may help to understand the etiological basis of this disorder and the 
      study may further strengthen the HLA antigens as the marker for schizophrenia.
FAU - Singh, Bisu
AU  - Singh B
FAU - Banerjee, Sikta
AU  - Banerjee S
FAU - Bera, Nirmal K
AU  - Bera NK
FAU - Nayak, Chitta R
AU  - Nayak CR
FAU - Chaudhuri, Tapas K
AU  - Chaudhuri TK
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC2738365
OTO - NOTNLM
OT  - Etiology
OT  - human leukocyte antigen
OT  - schizophrenia
COIS- Conflict of Interest: None declared
EDAT- 2008/07/01 00:00
MHDA- 2008/07/01 00:01
PMCR- 2008/07/01
CRDT- 2009/09/11 06:00
PHST- 2009/09/11 06:00 [entrez]
PHST- 2008/07/01 00:00 [pubmed]
PHST- 2008/07/01 00:01 [medline]
PHST- 2008/07/01 00:00 [pmc-release]
AID - IJP-50-166 [pii]
AID - 10.4103/0019-5545.43625 [doi]
PST - ppublish
SO  - Indian J Psychiatry. 2008 Jul;50(3):166-70. doi: 10.4103/0019-5545.43625.