PMID- 19744714
OWN - NLM
STAT- MEDLINE
DCOM- 20091020
LR  - 20101118
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 46
IP  - 16
DP  - 2009 Oct
TI  - Role of Cybr, a cytohesin binder and regulator, in CD4(+) T-cell function and 
      host immunity.
PG  - 3218-23
LID - 10.1016/j.molimm.2009.08.014 [doi]
AB  - Cytohesin binder and regulator (Cybr) is known to regulate leukocyte adhesion and 
      migration. However, its function in T-cells is poorly understood. Here, we 
      investigated the role of Cybr in CD4(+) T-cell function and host immunity. Cybr 
      inhibited p38 phosphorylation following CD4(+) T-cell stimulation. Since p38 
      regulates the expression of T-box expressed in T-cells (T-bet) but not GATA 
      binding protein 3 (GATA-3) in T-cells, Cybr decreased the expression of T-bet and 
      IFN-gamma in CD4(+) T-cells. Moreover, we found that host immunity against 
      Listeria infection and IFN-gamma production in blood were significantly 
      compromised in Cybr-overexpressing transgenic mice. In summary, our data suggest 
      that Cybr represses the expression of T-bet and IFN-gamma via an inhibition of 
      p38 in T-cells and consequently reduces host resistance to bacterial infection in 
      mice.
FAU - Chang, Shu-Lin
AU  - Chang SL
AD  - Agricultural Biotechnology Research Center, Academia Sinica, Nankang, Taipei, 
      Taiwan.
FAU - Chang, C Lee-Tian
AU  - Chang CL
FAU - Huang, Pei-Ing
AU  - Huang PI
FAU - Tao, Mi-Hua
AU  - Tao MH
FAU - Yang, Wen-Chin
AU  - Yang WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090909
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Carrier Proteins)
RN  - 0 (Cybr protein, mouse)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (Gata3 protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology/metabolism
MH  - Carrier Proteins/*immunology/metabolism
MH  - GATA3 Transcription Factor/biosynthesis/immunology
MH  - Gene Expression Regulation/*immunology
MH  - Interferon-gamma/biosynthesis/*immunology
MH  - Listeria monocytogenes/*immunology
MH  - Listeriosis/blood/*immunology
MH  - Membrane Proteins/*immunology/metabolism
MH  - Mice
MH  - Phosphorylation/immunology
MH  - T-Box Domain Proteins/biosynthesis/immunology
MH  - p38 Mitogen-Activated Protein Kinases/immunology/metabolism
EDAT- 2009/09/12 06:00
MHDA- 2009/10/21 06:00
CRDT- 2009/09/12 06:00
PHST- 2009/03/21 00:00 [received]
PHST- 2009/08/11 00:00 [revised]
PHST- 2009/08/12 00:00 [accepted]
PHST- 2009/09/12 06:00 [entrez]
PHST- 2009/09/12 06:00 [pubmed]
PHST- 2009/10/21 06:00 [medline]
AID - S0161-5890(09)00680-4 [pii]
AID - 10.1016/j.molimm.2009.08.014 [doi]
PST - ppublish
SO  - Mol Immunol. 2009 Oct;46(16):3218-23. doi: 10.1016/j.molimm.2009.08.014. Epub 
      2009 Sep 9.