PMID- 1974624
OWN - NLM
STAT- MEDLINE
DCOM- 19900918
LR  - 20190710
IS  - 0022-3573 (Print)
IS  - 0022-3573 (Linking)
VI  - 42
IP  - 3
DP  - 1990 Mar
TI  - Choline is an inhibitory modulator of cholinergic nerve function in guinea-pig 
      colon.
PG  - 211-3
AB  - Using the novel smooth muscle-myenteric plexus (smmp) preparation from the 
      guinea-pig colon, it has been possible to measure acetylcholine (ACh) overflow by 
      a radiolabelling technique. The possibility that choline may be a modulator of 
      cholinergic nerve activity in this preparation was investigated by observing its 
      effects on electrically-evoked overflow of [3H]acetylcholine. Choline (72, 144 
      microM), in concentrations that did not contract the smmp preparation, caused a 
      depression of electrically-evoked [3H]ACh overflow. This effect was unlikely to 
      be due to actions on cholinesterase enzymes by end product inhibition. Choline 
      also produced substantial non-muscarinic elevation of spontaneous [3H]overflow. 
      It is concluded that inhibitory modulation of enteric cholinergic nerve activity 
      by presynaptic muscarinic receptors may not be exclusively mediated by the 
      actions of acetylcholine.
FAU - Trout, S J
AU  - Trout SJ
AD  - Department of Pharmacology, London Hospital Medical College, UK.
FAU - Burleigh, D E
AU  - Burleigh DE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 7C0697DR9I (Atropine)
RN  - N91BDP6H0X (Choline)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Atropine/pharmacology
MH  - Choline/*pharmacology
MH  - Colon/drug effects/*innervation
MH  - Electric Stimulation
MH  - Guinea Pigs
MH  - In Vitro Techniques
MH  - Parasympathetic Nervous System/*drug effects
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
AID - 10.1111/j.2042-7158.1990.tb05392.x [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 1990 Mar;42(3):211-3. doi: 10.1111/j.2042-7158.1990.tb05392.x.