PMID- 1974657
OWN - NLM
STAT- MEDLINE
DCOM- 19900917
LR  - 20190828
IS  - 0300-9173 (Print)
IS  - 0300-9173 (Linking)
VI  - 27
IP  - 2
DP  - 1990 Mar
TI  - [A clinical study of drug-induced sinus node dysfunction].
PG  - 193-200
AB  - beta blockers and Ca antagonists are popular therapeutic agents for hypertension 
      and ischemic heart disease. Although these are reported to induce various 
      bradycardiac arrhythmias, clinical studies remain insufficient. The author 
      performed a clinical study of sinus node dysfunction caused by drugs for heart 
      and circulatory diseases. Seventy-seven of the 1,734 patients admitted to the CCU 
      of our hospital during the past 11 years, were the subjects of this study. They 
      showed sinus node dysfunction on electrocardiographs (ECG). Forty-two subjects 
      had drug-induced sinus node dysfunction (DISD) and 35 had sick sinus syndrome 
      (SSS). Rubenstein's classification based on 12-lead ECG was used to diagnose DISD 
      and SSS. All patients underwent chest X-ray examination, ECG, echocardiogram and 
      blood chemistry and were divided into DISD and SSS groups. The DISD group was 
      subdivided into an older group (65 years or more), and a younger group. Ten 
      patients in the DISD group were examined electrophysiologically. SSS II and III 
      types appeared in 22 DISD patients (52.3%) and in 31 SSS patients (88.5%). 
      Bradycardia in the DISD group was milder than in the SSS group, because the DISD 
      group had a higher minimum heart-rate and a shorter maximum R-R interval. 
      However, the DISD group showed significantly lower blood pressure and renal 
      function and a higher grade on the New York Heart Association's (NYHA) 
      classification. Echocardiographic findings following recovery were similar in the 
      two groups. Electrophysiological examination revealed abnormal sinus node 
      function in 3 of the 10 DISD patients (30.0%). In the DISD group, 27 were older 
      patients (3.2%). This was significantly more than the 15 who were younger 
      patients (1.6%).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Nakamura, T
AU  - Nakamura T
AD  - Second Department of Medicine, Teikyo University School of Medicine.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Ronen Igakkai Zasshi
JT  - Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
JID - 7507332
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Digitalis Glycosides)
SB  - IM
MH  - Adrenergic beta-Antagonists/adverse effects
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Arrhythmia Agents/adverse effects
MH  - Arrhythmia, Sinus/*chemically induced
MH  - Calcium Channel Blockers/adverse effects
MH  - Digitalis Glycosides/adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sick Sinus Syndrome/*chemically induced
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
AID - 10.3143/geriatrics.27.193 [doi]
PST - ppublish
SO  - Nihon Ronen Igakkai Zasshi. 1990 Mar;27(2):193-200. doi: 
      10.3143/geriatrics.27.193.