PMID- 19746676
OWN - NLM
STAT- MEDLINE
DCOM- 20090924
LR  - 20220421
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 8
IP  - 9
DP  - 2009 Sep
TI  - A randomized controlled trial of a low-dose combined oral contraceptive 
      containing 3 mg drospirenone plus 20 microg ethinylestradiol in the treatment of 
      acne vulgaris: lesion counts, investigator ratings and subject self-assessment.
PG  - 837-44
AB  - OBJECTIVE: To assess the efficacy of a combined oral contraceptive (COC) 
      containing 3 mg drospirenone (drsp) plus 20 microg ethinylestradiol (EE) 
      administered in 24 days of active treatment followed by a four-day hormone-free 
      interval (24/4 regimen) compared with placebo for the treatment of moderate acne 
      vulgaris. METHODS: Healthy females (14-45 years old) with moderate facial acne 
      were randomized to 3 mg drsp/20 microg EE 24/4 (n = 270) or placebo (n = 268) for 
      six cycles. The secondary efficacy variables measured included change from 
      baseline to endpoint (cycle 6) in individual lesion count for nodules, papules, 
      pustules, open and closed comedones. RESULTS: There were significantly greater 
      reductions in individual lesion counts from baseline to endpoint in the 3 mg 
      drsp/20 microg EE group than in the placebo group (P < 0.05 from parametric 
      model). CONCLUSION: The 3 mg drsp/20 microg EE COC administered in a 24/4 regimen 
      significantly reduced acne lesions.
FAU - Maloney, J Michael
AU  - Maloney JM
AD  - Cherry Creek Research, Inc, Denver, CO 80209, USA. 
      Drmaloney@cherrycreekdermatology.com
FAU - Dietze, Peter Jr
AU  - Dietze P Jr
FAU - Watson, David
AU  - Watson D
FAU - Niknian, Minoo
AU  - Niknian M
FAU - Lee-Rugh, Sooji
AU  - Lee-Rugh S
FAU - Sampson-Landers, Carole
AU  - Sampson-Landers C
FAU - Korner, Paul
AU  - Korner P
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (Androstenes)
RN  - 0 (Contraceptives, Oral, Combined)
RN  - 423D2T571U (Ethinyl Estradiol)
RN  - N295J34A25 (drospirenone)
SB  - IM
MH  - Acne Vulgaris/*drug therapy
MH  - Adolescent
MH  - Adult
MH  - Androstenes/adverse effects/*therapeutic use
MH  - Contraceptives, Oral, Combined/adverse effects/*therapeutic use
MH  - Double-Blind Method
MH  - Ethinyl Estradiol/adverse effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/09/15 06:00
MHDA- 2009/09/25 06:00
CRDT- 2009/09/15 06:00
PHST- 2009/09/15 06:00 [entrez]
PHST- 2009/09/15 06:00 [pubmed]
PHST- 2009/09/25 06:00 [medline]
PST - ppublish
SO  - J Drugs Dermatol. 2009 Sep;8(9):837-44.