PMID- 19747262
OWN - NLM
STAT- MEDLINE
DCOM- 20091020
LR  - 20151119
IS  - 1742-4658 (Electronic)
IS  - 1742-464X (Linking)
VI  - 276
IP  - 20
DP  - 2009 Oct
TI  - Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase.
PG  - 5892-905
LID - 10.1111/j.1742-4658.2009.07273.x [doi]
AB  - A novel gene ZC3H12A, encoding MCP-1-induced protein 1 (MCPIP), was recently 
      identified in human peripheral blood monocytes treated with monocyte chemotactic 
      protein 1 (MCP-1) and in human monocyte-derived macrophages stimulated with 
      interleukin (IL)-1beta. These experiments revealed that the gene undergoes rapid 
      and potent transcription induction upon stimulation with proinflammatory 
      molecules, such as MCP-1, IL-1beta, tumour necrosis factor alpha and 
      lipopolysaccharide. Here we show that the induction of ZC3H12A by IL-1beta is 
      predominantly NF-kappaB-dependent because inhibition of this signalling pathway 
      results in the impairment of ZC3H12A transcription activation. Our results 
      indicate the presence of an IL-1beta-responding region within the second intron 
      of the ZC3H12A gene, which contains four functional NF-kappaB-binding sites. 
      Therefore, we propose that this transcription enhancer transduces a ZC3H12A 
      transcription-inducing signal after IL-1beta stimulation. Recent reports suggest 
      that MCPIP acts as a negative regulator of inflammatory processes because it is 
      engaged in the degradation of transcripts coding for certain proinflammatory 
      cytokines. Our observations provide evidence for a novel negative feedback loop 
      in the activation of NF-kappaB and point to potential significance of MCPIP in 
      the treatment of various pathological states, such as diabetes or cancer that 
      involve disturbances in the functioning of the NF-kappaB system.
FAU - Skalniak, Lukasz
AU  - Skalniak L
AD  - Department of Cell Biochemistry, Faculty of Biochemistry, Jagiellonian 
      University, Krakow, Poland.
FAU - Mizgalska, Danuta
AU  - Mizgalska D
FAU - Zarebski, Adrian
AU  - Zarebski A
FAU - Wyrzykowska, Paulina
AU  - Wyrzykowska P
FAU - Koj, Aleksander
AU  - Koj A
FAU - Jura, Jolanta
AU  - Jura J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090911
PL  - England
TA  - FEBS J
JT  - The FEBS journal
JID - 101229646
RN  - 0 (I-kappa B Proteins)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NF-kappa B)
RN  - 0 (Transcription Factors)
RN  - EC 3.1.- (Ribonucleases)
RN  - EC 3.1.- (ZC3H12A protein, human)
SB  - IM
MH  - Base Sequence
MH  - Binding Sites/genetics
MH  - Blotting, Western
MH  - Cell Line, Tumor
MH  - Chromatin Immunoprecipitation
MH  - Electrophoretic Mobility Shift Assay
MH  - Humans
MH  - I-kappa B Proteins/genetics/physiology
MH  - Interleukin-1beta/pharmacology
MH  - Molecular Sequence Data
MH  - Mutagenesis, Site-Directed
MH  - NF-kappa B/genetics/*metabolism
MH  - Polymerase Chain Reaction
MH  - Ribonucleases
MH  - Signal Transduction/drug effects/genetics
MH  - Transcription Factors/genetics/*metabolism
MH  - Transcription Initiation Site
MH  - Transcription, Genetic/genetics
EDAT- 2009/09/15 06:00
MHDA- 2009/10/21 06:00
CRDT- 2009/09/15 06:00
PHST- 2009/09/15 06:00 [entrez]
PHST- 2009/09/15 06:00 [pubmed]
PHST- 2009/10/21 06:00 [medline]
AID - EJB7273 [pii]
AID - 10.1111/j.1742-4658.2009.07273.x [doi]
PST - ppublish
SO  - FEBS J. 2009 Oct;276(20):5892-905. doi: 10.1111/j.1742-4658.2009.07273.x. Epub 
      2009 Sep 11.