PMID- 19748249
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20171116
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 20
IP  - 10
DP  - 2010 Dec
TI  - Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati 
      subjects classified with the metabolic syndrome.
PG  - 720-6
LID - 10.1016/j.numecd.2009.06.004 [doi]
AB  - BACKGROUND AND AIMS: Carbohydrate restriction (CR) has been shown to improve 
      dyslipidemias associated with metabolic syndrome (MetS). We evaluated the effects 
      of CR on lipoprotein subfractions and apolipoproteins in Emirati adults 
      classified with the MetS. METHODS AND RESULTS: 39 subjects (15 men/24 women) were 
      randomly allocated to a CR diet [20-25% energy from carbohydrate (CHO)] for 12 wk 
      (CRD group) or a combination treatment consisting of CRD for 6 wk followed by the 
      American Heart Association diet (50-55% CHO, AHA group) for an additional 6 wk. 
      All subjects reduced body weight, LDL cholesterol and triglycerides (P<0.01). At 
      baseline all subjects had low concentrations of medium VLDL and total HDL 
      particles associated with the very low plasma triglycerides and HDL cholesterol 
      in this population. After 12 wk, the large VLDL subfraction was decreased over 
      time for subjects in the CRD group (P<0.01) while these changes were not observed 
      in those subjects who changed to the AHA diet. The number of medium and small LDL 
      particles decreased for all subjects rendering a less atherogenic lipoprotein 
      profile. In agreement with these results, a significant decrease in 
      apolipoprotein (apo) B was observed (P<0.01). The medium HDL subfraction and apo 
      A-II, which can be considered pro-atherogenic, were also decreased over time in 
      the CRD group only. CONCLUSIONS: These results suggest that weight loss favorably 
      affects lipoprotein metabolism and that the CRD had a better effect on 
      atherogenic VLDL and HDL than the low fat diet recommended by AHA.
CI  - Copyright (c) 2009 Elsevier B.V. All rights reserved.
FAU - Al-Sarraj, T
AU  - Al-Sarraj T
AD  - Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, 
      USA.
FAU - Saadi, H
AU  - Saadi H
FAU - Volek, J S
AU  - Volek JS
FAU - Fernandez, M L
AU  - Fernandez ML
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20090912
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Apolipoproteins)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Apolipoproteins/analysis
MH  - Body Composition
MH  - Body Weight
MH  - Cholesterol, HDL/blood/*metabolism
MH  - Cholesterol, LDL/blood/*metabolism
MH  - *Diet, Carbohydrate-Restricted
MH  - Dietary Carbohydrates/administration & dosage
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*epidemiology
MH  - Middle Aged
MH  - Triglycerides/blood
MH  - United Arab Emirates
MH  - Young Adult
EDAT- 2009/09/15 06:00
MHDA- 2011/05/20 06:00
CRDT- 2009/09/15 06:00
PHST- 2009/03/10 00:00 [received]
PHST- 2009/06/04 00:00 [revised]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2009/09/15 06:00 [entrez]
PHST- 2009/09/15 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - S0939-4753(09)00143-4 [pii]
AID - 10.1016/j.numecd.2009.06.004 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2010 Dec;20(10):720-6. doi: 
      10.1016/j.numecd.2009.06.004. Epub 2009 Sep 12.