PMID- 1974853
OWN - NLM
STAT- MEDLINE
DCOM- 19900927
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 181
IP  - 1-2
DP  - 1990 May 31
TI  - Reversal of the acute effects of 3,4-methylenedioxymethamphetamine by 5-HT uptake 
      inhibitors.
PG  - 133-6
AB  - Recent evidence suggests that the acute 3,4-methylenedioxymethamphetamine 
      (MDMA)-induced loss of tryptophan hydroxylase activity (TPH) may be due to the 
      oxidation of critical sulf-hydryl groups on the molecule. To determine if TPH 
      activity could be regenerated in vivo we administered a 5-HT uptake inhibitor at 
      various times immediately after MDMA. Although enzyme activity began to decline 
      immediately following MDMA administration, rats receiving the uptake inhibitor 1 
      h post MDMA showed a rapid recovery of TPH activity. Administration of an uptake 
      inhibitor 3 h post MDMA was without effect on the time course of TPH 
      inactivation. The results suggest that systems exist within the serotonergic 
      neuron for the reductive regeneration of active TPH. Furthermore, these systems 
      are acutely compromised following the administration of MDMA.
FAU - Schmidt, C J
AU  - Schmidt CJ
AD  - Merrell Dow Research Institute, Cincinnati, OH 45215.
FAU - Taylor, V L
AU  - Taylor VL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Indenes)
RN  - 0 (Serotonin Antagonists)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 130835-44-8 (MDL 27777)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*antagonists & inhibitors
MH  - Amphetamines/*antagonists & inhibitors
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - Fluoxetine/pharmacology
MH  - Indenes/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*metabolism
MH  - Serotonin Antagonists/*pharmacology
MH  - Tryptophan Hydroxylase/*antagonists & inhibitors
EDAT- 1990/05/31 00:00
MHDA- 1990/05/31 00:01
CRDT- 1990/05/31 00:00
PHST- 1990/05/31 00:00 [pubmed]
PHST- 1990/05/31 00:01 [medline]
PHST- 1990/05/31 00:00 [entrez]
AID - 0014-2999(90)90254-4 [pii]
AID - 10.1016/0014-2999(90)90254-4 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1990 May 31;181(1-2):133-6. doi: 10.1016/0014-2999(90)90254-4.