PMID- 1974858
OWN - NLM
STAT- MEDLINE
DCOM- 19900927
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 181
IP  - 1-2
DP  - 1990 May 31
TI  - Antagonism of the neurotoxicity due to a single administration of 
      methylenedioxymethamphetamine.
PG  - 59-70
AB  - The role of transmitter release in the serotonergic neurotoxicity of 
      methylenedioxymethamphetamine (MDMA) was examined using treatments altering 
      MDMA-induced release or its consequences. The long-term decrease in 5-HT 
      concentrations and tryptophan hydroxylase activity produced by MDMA was 
      antagonized by depletion of vesicular monoamines with reserpine or interruption 
      of monoamine synthesis with the decarboxylase inhibitor, monofluoromethyl DOPA 
      (dihydroxyphenylalanine). Similar results were achieved by selectively inhibiting 
      dopamine synthesis with alpha-methyl-p-tyrosine or through bilateral lesions of 
      the substantia nigra with 6-hydroxydopamine. The dopamine receptor antagonist 
      haloperidol was also effective in this regard. Although these results strongly 
      implicate dopamine release in the long-term neurochemical effects of MDMA, 
      protection was also provided by selective 5-HT2 antagonists indicating that the 
      neurotoxicity is dependent upon the release of both dopamine and 5-HT.
FAU - Schmidt, C J
AU  - Schmidt CJ
AD  - Merrell Dow Research Institute, Cincinnati, OH 45215.
FAU - Black, C K
AU  - Black CK
FAU - Taylor, V L
AU  - Taylor VL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Aromatic Amino Acid Decarboxylase Inhibitors)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Catecholamines)
RN  - 0 (Hydroxydopamines)
RN  - 0 (Indoles)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 64-12-0 (p-Chloroamphetamine)
RN  - 8B1QWR724A (Reserpine)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/antagonists & 
      inhibitors/*toxicity
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Aromatic Amino Acid Decarboxylase Inhibitors
MH  - Biogenic Monoamines/metabolism
MH  - Brain/drug effects/enzymology
MH  - Catecholamines/metabolism
MH  - Hydroxydopamines
MH  - Indoles/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Nervous System Diseases/*prevention & control
MH  - Oxidopamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reserpine/pharmacology
MH  - Serotonin/metabolism
MH  - Substantia Nigra/cytology/drug effects/metabolism
MH  - Tryptophan Hydroxylase/metabolism
MH  - p-Chloroamphetamine/pharmacology
EDAT- 1990/05/31 00:00
MHDA- 1990/05/31 00:01
CRDT- 1990/05/31 00:00
PHST- 1990/05/31 00:00 [pubmed]
PHST- 1990/05/31 00:01 [medline]
PHST- 1990/05/31 00:00 [entrez]
AID - 0014-2999(90)90245-2 [pii]
AID - 10.1016/0014-2999(90)90245-2 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1990 May 31;181(1-2):59-70. doi: 10.1016/0014-2999(90)90245-2.