PMID- 19751235
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20220331
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Linking)
VI  - 100
IP  - 12
DP  - 2009 Dec
TI  - Human leukocyte antigen class I down-regulation in muscle-invasive bladder 
      cancer: its association with clinical characteristics and survival after 
      cystectomy.
PG  - 2331-4
LID - 10.1111/j.1349-7006.2009.01329.x [doi]
AB  - Using a novel monoclonal anti-pan human leukocyte antigen (HLA) class I heavy 
      chain antibody (EMR 8-5) reacting with paraffin-embedded sections, we examined 
      the prognostic significance of HLA class I molecules in muscle-invasive bladder 
      cancer patients who underwent radical cystectomy. Immunohistochemical staining 
      for HLA class I molecules with monoclonal antibody EMR 8-5 was performed on 
      specimens from 65 clinically muscle-invasive bladder cancer patients who 
      underwent radical cystectomy and pelvic lymph node dissection without neoadjuvant 
      chemotherapy. We analyzed the clinicopathological and prognostic significance of 
      HLA class I expression. Immunohistochemical analysis revealed HLA class I 
      down-regulation in 22 (33.8%) invasive bladder cancers. This down-regulation had 
      no correlation with clinicopathological parameters such as pathologic stage, 
      nodal status, and grade. The recurrence-free survival of patients with HLA class 
      I-positive tumors was significantly better than that of those with 
      down-regulation (log rank, P = 0.0337). Multivariate analysis revealed that HLA 
      class I expression was a significant factor influencing the recurrence-free 
      survival of bladder cancer patients after cystectomy (P = 0.0155). Our data 
      demonstrate that HLA class I down-regulation in tumor cells was clearly observed 
      in about one-third of the patients. HLA class I expression could be a prognostic 
      marker for muscle-invasive bladder cancer patients after cystectomy.
FAU - Homma, Ichiya
AU  - Homma I
AD  - Department of Urology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan. ichiya@sapmed.ac.jp
FAU - Kitamura, Hiroshi
AU  - Kitamura H
FAU - Torigoe, Toshihiko
AU  - Torigoe T
FAU - Tanaka, Toshiaki
AU  - Tanaka T
FAU - Sato, Eiji
AU  - Sato E
FAU - Hirohashi, Yoshihiko
AU  - Hirohashi Y
FAU - Masumori, Naoya
AU  - Masumori N
FAU - Sato, Noriyuki
AU  - Sato N
FAU - Tsukamoto, Taiji
AU  - Tsukamoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090827
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cystectomy
MH  - Down-Regulation
MH  - Female
MH  - *Genes, MHC Class I
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - Urinary Bladder Neoplasms/*immunology/mortality/pathology/surgery
EDAT- 2009/09/16 06:00
MHDA- 2010/03/20 06:00
CRDT- 2009/09/16 06:00
PHST- 2009/09/16 06:00 [entrez]
PHST- 2009/09/16 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - CAS1329 [pii]
AID - 10.1111/j.1349-7006.2009.01329.x [doi]
PST - ppublish
SO  - Cancer Sci. 2009 Dec;100(12):2331-4. doi: 10.1111/j.1349-7006.2009.01329.x. Epub 
      2009 Aug 27.