PMID- 1975283
OWN - NLM
STAT- MEDLINE
DCOM- 19901002
LR  - 20190711
IS  - 0023-2173 (Print)
IS  - 0023-2173 (Linking)
VI  - 68
IP  - 14
DP  - 1990 Jul 17
TI  - Assessment of local cellular immunity in lung cancer by bronchoalveolar lavage.
PG  - 728-34
AB  - Small cell lung cancer (SCLC) is the most malignant of the pulmonary neoplasms 
      and is associated with a poor local cellular immune response. 16 patients with 
      non small cell lung cancer (NSCLC) and 11 patients with SCLC underwent 
      bronchoalveolar lavage (BAL) in the lung which harbored the tumor in order to 
      investigate the lymphocyte surface antigens utilizing the immunoperoxidase 
      technique. Analysis of blood lymphocytes was performed in parallel. 8 patients 
      with previous sarcoidosis in complete remission who underwent BAL and 10 normal 
      blood donors served as controls. Among blood lymphocytes the CD3+, CD4+ and CD16+ 
      cell populations were elevated significantly and the T4/T8 ratio was elevated in 
      NSCLC patients, but only CD16+ were augmented in SCLC. Cell populations 
      expressing the activation markers transferrin (TF) receptor, interleukin-2 (IL-2) 
      receptor and the very late antigen VAL-1 were also increased in NSCLC, while SCLC 
      was associated with antigen distributions similar to controls. No differences 
      between the cohorts were seen in the expression of human leukocyte antigen 
      (HLA)-DR. In BAL the population of CD3+ and CD4+ cells were reduced in SCLC and 
      the T4/T8 ratio was diminished in contrast to controls and NSCLC patients, 
      whereas these two latter groups did not differ from each other. The distribution 
      pattern of CD16, TF receptor and IL-2 receptor in the study groups resembled that 
      of cells of the blood stream, but CD16+ natural killer cells were additionally 
      down regulated to control values in SCLC. No differences were seen in the 
      distribution of VLA-1. HLA-DR+ cells were clearly elevated in both cancer 
      groups.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Lorenz, J
AU  - Lorenz J
AD  - III. Medizinische Klinik mit Schwerpunkt Pneumologie Klinikum, Johannes 
      Gutenberg-Universitat Mainz.
FAU - Muller-Quernheim, J
AU  - Muller-Quernheim J
FAU - Castillo-Hofer, C
AU  - Castillo-Hofer C
FAU - Doboszynska, A
AU  - Doboszynska A
FAU - Ferlinz, R
AU  - Ferlinz R
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Klin Wochenschr
JT  - Klinische Wochenschrift
JID - 2985205R
RN  - 0 (Antigens, CD)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Adenocarcinoma/immunology
MH  - Antigens, CD/analysis
MH  - Bronchoalveolar Lavage Fluid/*cytology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Carcinoma, Non-Small-Cell Lung/*immunology
MH  - Carcinoma, Small Cell/*immunology
MH  - Carcinoma, Squamous Cell/immunology
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Leukocyte Count
MH  - Lung Neoplasms/*immunology
MH  - Receptors, Interleukin-2/analysis
MH  - T-Lymphocytes/*immunology
EDAT- 1990/07/17 00:00
MHDA- 1990/07/17 00:01
CRDT- 1990/07/17 00:00
PHST- 1990/07/17 00:00 [pubmed]
PHST- 1990/07/17 00:01 [medline]
PHST- 1990/07/17 00:00 [entrez]
AID - 10.1007/BF01647581 [doi]
PST - ppublish
SO  - Klin Wochenschr. 1990 Jul 17;68(14):728-34. doi: 10.1007/BF01647581.