PMID- 19753523
OWN - NLM
STAT- MEDLINE
DCOM- 20091123
LR  - 20220330
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 16
IP  - 5
DP  - 2009
TI  - Assessment of left ventricle diastolic function in myocardial infarction patients 
      treated with primary angioplasty.
PG  - 440-6
AB  - BACKGROUND: More than 5% of patients over the age of 65 have been found to 
      develop heart failure, and over half of them preserve normal left ventricular 
      systolic function. In the last few years, diastolic heart failure has become a 
      serious clinical and epidemiological problem. METHODS: This prospective study was 
      carried out on 99 patients. Patients were evaluated up to three months after 
      primary percutaneous coronary intervention (PCI). Evaluation was performed three 
      times: within the first 24 hours after primary PCI, on day seven after PCI and at 
      three months after PCI. We analyzed the relationship between the severity of left 
      ventricle diastolic dysfunction and atherosclerosis risk factors, infarction 
      site, maximum levels of cardiac biomarkers such as troponin I, CPK and CK-MB, CRP 
      protein levels, angioplasty effectiveness, reperfusion time, TIMI and TMPG grade. 
      RESULTS: Most patients with ST elevation myocardial infarction (STEMI) treated 
      with primary PCI demonstrated left ventricle diastolic dysfunction on the first 
      day of myocardial infarction. Levels of cardiac biomarkers were significantly 
      higher in patients with restrictive filling pattern. The inflammatory response 
      (CRP levels) was found to have an important role in the development of diastolic 
      abnormalities. There was a close relationship between diastolic and systolic 
      function. Average values of left ventricular ejection fraction in patients with 
      restrictive filling pattern were significantly lower than in those with impaired 
      relaxation (44.7 vs. 52.7%; p < 0.001) and normal filling (54.2%; p = 0.002). 
      CONCLUSIONS: More than half of patients with a first STEMI have left ventricle 
      diastolic dysfunction within the first day after PCI, and these abnormalities are 
      still present three months after PCI. Time and effectiveness of reperfusion, CRP 
      level, troponin I, max, CPK max and CK-MB max levels as well as left ventricular 
      ejection fraction have an important influence on the development of diastolic 
      dysfunction. Infarct extension contributes significantly to the process.
FAU - Misztal, Marcin
AU  - Misztal M
AD  - Coronary Artery Disease Department, Institute of Cardiology, Jagiellonian 
      University, Krakow, Poland. mamis@interia.pl
FAU - Stopyra, Katarzyna
AU  - Stopyra K
FAU - Gackowski, Andrzej
AU  - Gackowski A
FAU - Zmudka, Krzysztof
AU  - Zmudka K
FAU - Piwowarska, Wieslawa
AU  - Piwowarska W
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Troponin I)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angioplasty, Balloon, Coronary/*adverse effects
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Creatine Kinase/blood
MH  - Creatine Kinase, MB Form/blood
MH  - Diastole
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/diagnostic 
      imaging/pathology/physiopathology/*therapy
MH  - Myocardium/pathology
MH  - Necrosis
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Troponin I/blood
MH  - Ultrasonography
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*etiology/physiopathology
MH  - *Ventricular Function, Left
EDAT- 2009/09/16 06:00
MHDA- 2009/12/16 06:00
CRDT- 2009/09/16 06:00
PHST- 2009/09/16 06:00 [entrez]
PHST- 2009/09/16 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PST - ppublish
SO  - Cardiol J. 2009;16(5):440-6.