PMID- 19753653
OWN - NLM
STAT- MEDLINE
DCOM- 20100208
LR  - 20191210
IS  - 1872-8081 (Electronic)
IS  - 0951-6433 (Linking)
VI  - 35
IP  - 5
DP  - 2009 Sep-Oct
TI  - Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese 
      diabetic KK-Ay mice.
PG  - 442-8
LID - 10.1002/biof.58 [doi]
AB  - Terpenoids, which are contained in a large number of dietary and herbal plants, 
      have many biological effects. In this study, the effects of dehydroabietic acid 
      (DAA), a diterpene, on glucose and lipid metabolism were examined using obese 
      diabetic KK-Ay mice. We showed here that DAA treatment decreased not only plasma 
      glucose and insulin levels but also plasma triglyceride (TG) and hepatic TG 
      levels. To examine the mechanism underlying the effects of DAA, the production of 
      inflammatory cytokines was measured. It was shown that the DAA treatment 
      suppressed the production of monocyte chemoattractant protein-1 (MCP-1) and tumor 
      necrosis factor-alpha (TNFalpha) (proinflammatory cytokines) and increased that 
      of adiponectin (an anti-inflammatory cytokine). As a result of the changes in the 
      production of inflammatory cytokines caused by the DAA treatment, the 
      accumulation of macrophages in adipose tissues was reduced. These results 
      indicate that treatment with DAA improves the levels of plasma glucose, plasma 
      insulin, plasma TG, and hepatic TG through the decrease in the macrophage 
      infiltration into adipose tissues, suggesting that DAA is a useful food-derived 
      compound for treating obesity-related diseases.
CI  - Copyright 2009 International Union of Biochemistry and Molecular Biology, Inc.
FAU - Kang, Min-Sook
AU  - Kang MS
AD  - Laboratory of Molecular Function of Food, Division of Food Science and 
      Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 
      Japan.
FAU - Hirai, Shizuka
AU  - Hirai S
FAU - Goto, Tsuyoshi
AU  - Goto T
FAU - Kuroyanagi, Kayo
AU  - Kuroyanagi K
FAU - Kim, Young-Il
AU  - Kim YI
FAU - Ohyama, Kana
AU  - Ohyama K
FAU - Uemura, Taku
AU  - Uemura T
FAU - Lee, Joo-Young
AU  - Lee JY
FAU - Sakamoto, Tomoya
AU  - Sakamoto T
FAU - Ezaki, Yoichiro
AU  - Ezaki Y
FAU - Yu, Rina
AU  - Yu R
FAU - Takahashi, Nobuyuki
AU  - Takahashi N
FAU - Kawada, Teruo
AU  - Kawada T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
RN  - 0 (Abietanes)
RN  - 0 (Adiponectin)
RN  - 0 (Adipoq protein, mouse)
RN  - 0 (Blood Glucose)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0S5XP6S3AU (dehydroabietic acid)
SB  - IM
EIN - Biofactors. 2010 May-Jun;36(3):240
MH  - Abietanes/*therapeutic use
MH  - Adiponectin/biosynthesis
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Chemokine CCL2/biosynthesis
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy
MH  - Hyperlipidemias/*drug therapy
MH  - Insulin/blood
MH  - Macrophages/drug effects/physiology
MH  - Mice
MH  - Mice, Obese
MH  - Obesity/complications
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 2009/09/16 06:00
MHDA- 2010/02/09 06:00
CRDT- 2009/09/16 06:00
PHST- 2009/09/16 06:00 [entrez]
PHST- 2009/09/16 06:00 [pubmed]
PHST- 2010/02/09 06:00 [medline]
AID - 10.1002/biof.58 [doi]
PST - ppublish
SO  - Biofactors. 2009 Sep-Oct;35(5):442-8. doi: 10.1002/biof.58.