PMID- 19754213
OWN - NLM
STAT- MEDLINE
DCOM- 20091110
LR  - 20170214
IS  - 1533-0346 (Print)
IS  - 1533-0338 (Linking)
VI  - 8
IP  - 5
DP  - 2009 Oct
TI  - Dosimetric comparisons of three-dimensional conformal radiotherapy, 
      intensity-modulated radiotherapy, and helical tomotherapy in whole abdominopelvic 
      radiotherapy for gynecologic malignancy.
PG  - 369-77
AB  - OBJECTIVES: The goal of this study was to dosimetrically compare 3-dimensional 
      radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and helical 
      tomotherapy (TOMO) plans for whole abdominopelvic radiotherapy (WART) in patients 
      with gynecologic cancer. METHODS: Ten patients were selected for WART planning. 
      Doses were prescribed to planning target volumes (PTVs) as the followings: 30 Gy 
      to PTV-whole abdominopelvis (PTV-WA), 40 Gy to PTV-para-aortic lymph node 
      (PTV-PALN), 44 Gy to PTV-pelvis, and 50 Gy to gross target volume (GTV) in 20 
      fractions. Dose to whole liver, both kidneys, and spinal cord were constrained 
      below each tissue tolerance, and bone marrow (BM)-sparing technique was adopted 
      in IMRT and TOMO. Dosimetric parameters and treatment times were compared among 
      plans. RESULTS: Calculated doses in TOMO came most closely to the prescribed dose 
      for coverage of PTV-WA, PTV-PALN, PTV-pelvis, and GTV compared to 3DCRT, and 
      IMRT. In normal organs, TOMO had significantly better dosimetric profiles 
      compared to IMRT and 3DCRT. TOMO significantly reduced V(20Gy), and mean dose of 
      whole liver, both kidneys, and spinal cord. The use of BM-sparing technique (BMS) 
      did not impair coverage of target volume in IMRT and TOMO. While IMRT showed no 
      differences of irradiated BM dose using BMS, TOMO with BMS reduced half V(20Gy) 
      of BM compared to TOMO without BMS. CONCLUSIONS: TOMO showed dosimetric 
      superiority in target coverage, sparing BM, and other normal organs compared to 
      3DCRT and IMRT. Clinical experiences will be needed for evaluation of feasibility 
      of WART using TOMO in patients with gynecologic cancer.
FAU - Kim, Yong Bae
AU  - Kim YB
AD  - Department of Radiation Oncology Yonsei Cancer Center, Brain Korea 21 Project for 
      Medical Sciences Yonsei University College of Medicine, Seoul, Korea.
FAU - Kim, Joo Ho
AU  - Kim JH
FAU - Jeong, Kyung Keun
AU  - Jeong KK
FAU - Seong, Jinsil
AU  - Seong J
FAU - Suh, Chang Ok
AU  - Suh CO
FAU - Kim, Gwi Eon
AU  - Kim GE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
SB  - IM
MH  - Abdominal Neoplasms/*radiotherapy/secondary/surgery
MH  - Computer Simulation
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Genital Neoplasms, Female/pathology/*radiotherapy/surgery
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Pelvic Neoplasms/*radiotherapy/secondary/surgery
MH  - Prognosis
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Radiotherapy, Conformal/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Tomography, Spiral Computed/*methods
MH  - Treatment Outcome
EDAT- 2009/09/17 06:00
MHDA- 2009/11/11 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2009/11/11 06:00 [medline]
AID - d=3036&c=4295&p=17742&do=detail [pii]
AID - 10.1177/153303460900800507 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2009 Oct;8(5):369-77. doi: 10.1177/153303460900800507.