PMID- 19754647
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20220310
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 39
IP  - 2
DP  - 2010 Feb
TI  - Differential infiltration of CD8+ and NK cells in lip and oral cavity squamous 
      cell carcinoma.
PG  - 162-7
LID - 10.1111/j.1600-0714.2009.00792.x [doi]
AB  - BACKGROUND: CD8+ and natural killer (NK) cells have been considered the most 
      effective cells in the combat of cancer, contributing to better prognosis and 
      longer survival. METHODS: The aim of this study was to evaluate the population of 
      CD8+ and NK cells, by immunohistochemistry, in samples of oral cavity squamous 
      cell carcinoma (OCSCC) and lip squamous cell carcinoma (LSCC), leukoplakia, 
      actinic cheilitis, and healthy oral mucosa (control). The relationship of CD8+ 
      and NK cells with survival data, lymph node metastasis, tumor size, and 
      proliferative index was also evaluated. RESULTS: The number of peritumoral and 
      intratumoral CD8+ and NK cells was significantly higher in LSCC, when compared 
      with control, pre-malignant lesions, and OCSCC. A higher proportion of 
      peritumoral CD8+ cells demonstrated correlation with a lower neoplastic 
      proliferative index. Moreover, patients with OCSCC with a high density of 
      peritumoral CD8+ cells showed a tendency towards a longer survival time. 
      CONCLUSIONS: The differential CD8+ and NK cells infiltration in oral SCC might 
      reflect a distinctive tumor microenvironment with a favorable local cytotoxic 
      immune response against neoplastic cells.
FAU - Zancope, E
AU  - Zancope E
AD  - Department of Stomatology (Oral Pathology), Dental School, Faculty of Pharmacy, 
      Federal University of Goias, Goiania, Brazil.
FAU - Costa, N L
AU  - Costa NL
FAU - Junqueira-Kipnis, A P
AU  - Junqueira-Kipnis AP
FAU - Valadares, M C
AU  - Valadares MC
FAU - Silva, T A
AU  - Silva TA
FAU - Leles, C R
AU  - Leles CR
FAU - Mendonca, E F
AU  - Mendonca EF
FAU - Batista, A C
AU  - Batista AC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090914
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (CCNB1 protein, human)
RN  - 0 (Cyclin B1)
SB  - IM
MH  - CD8-Positive T-Lymphocytes/*immunology/pathology
MH  - Carcinoma, Squamous Cell/*immunology/pathology/secondary
MH  - Cheilitis/immunology/pathology
MH  - Cyclin B1/analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Killer Cells, Natural/*immunology/pathology
MH  - Leukoplakia, Oral/immunology/pathology
MH  - Lip Neoplasms/*immunology/pathology
MH  - Lymphatic Metastasis/pathology
MH  - Lymphocyte Count
MH  - Lymphocytes, Tumor-Infiltrating/*immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Mitotic Index
MH  - Mouth Mucosa/immunology/pathology
MH  - Mouth Neoplasms/*immunology/pathology
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Survival Rate
EDAT- 2009/09/17 06:00
MHDA- 2010/07/16 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - JOP792 [pii]
AID - 10.1111/j.1600-0714.2009.00792.x [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2010 Feb;39(2):162-7. doi: 10.1111/j.1600-0714.2009.00792.x. 
      Epub 2009 Sep 14.