PMID- 19755645
OWN - NLM
STAT- MEDLINE
DCOM- 20100216
LR  - 20150427
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 18
IP  - 10
DP  - 2009 Oct
TI  - Sexually transmitted infections and prostate cancer among men in the U.S. 
      military.
PG  - 2665-71
LID - 10.1158/1055-9965.EPI-08-1167 [doi]
AB  - Studies of self-reported sexually transmitted infections (STI) suggesting an 
      association with prostate cancer may reflect underreporting of such infections 
      among nondiseased subjects. To reduce such bias, we studied archived sera in a 
      cohort of U.S. military personnel known to have high rates of both STIs and 
      prostate cancer. Using a nested case-control design, serum samples from 534 men 
      who served on active duty between September 1, 1993 and September 1, 2003 were 
      examined. Controls were individually matched to cases based on date of serum 
      collection, date of birth, branch of service, military rank, marital status, and 
      race. Each of the 267 case-control pairs had two serum samples: a recent serum 
      sample, taken approximately 1 year before the case's prostate cancer diagnosis, 
      and an earlier serum sample, taken approximately 8 years before diagnosis. Each 
      serum specimen was studied for antibodies against human papillomavirus, herpes 
      simplex virus-2 (HSV-2), and Chlamydia trachomatis. Logistic regression accounted 
      for matching and potential confounding factors. Study data indicated no 
      association between prostate cancer and serologic evidence of infections just 
      before the reference date. However, a statistically significant association 
      between prostate cancer and serologic evidence of HSV-2 infection was detected in 
      the earlier sample (odds ratio, 1.60; 95% confidence interval, 1.05-2.44). The 
      strength of this association increased when analyses were restricted to sera 
      collected at least 60 months before diagnosis (odds ratio, 2.04; 95% confidence 
      interval, 1.26-3.29; 204 pairs). If this association is causal, then our findings 
      would suggest a long latency period for prostate cancer development after HSV-2 
      infection.
FAU - Dennis, Leslie K
AU  - Dennis LK
AD  - Department of Epidemiology, College of Public Health, University of Iowa, 200 
      Hawkins Drive C21-G GH, Iowa City, IA 52242, USA. leslie-dennis@uiowa.edu
FAU - Coughlin, Julie A
AU  - Coughlin JA
FAU - McKinnon, Brittany C
AU  - McKinnon BC
FAU - Wells, Timothy S
AU  - Wells TS
FAU - Gaydos, Charlotte A
AU  - Gaydos CA
FAU - Hamsikova, Eva
AU  - Hamsikova E
FAU - Gray, Gregory C
AU  - Gray GC
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090915
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chlamydia Infections/epidemiology
MH  - Cohort Studies
MH  - Herpes Simplex/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Military Personnel
MH  - Papillomavirus Infections/epidemiology
MH  - Prostatic Neoplasms/blood/*epidemiology/virology
MH  - Risk Factors
MH  - Sexually Transmitted Diseases/blood/*epidemiology/virology
MH  - United States
EDAT- 2009/09/17 06:00
MHDA- 2010/02/17 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2010/02/17 06:00 [medline]
AID - 1055-9965.EPI-08-1167 [pii]
AID - 10.1158/1055-9965.EPI-08-1167 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2665-71. doi: 
      10.1158/1055-9965.EPI-08-1167. Epub 2009 Sep 15.