PMID- 19755790
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20220408
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 16
IP  - 6
DP  - 2009
TI  - CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients 
      with stroke.
PG  - 707-13
AB  - AIM: Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte 
      chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with 
      acute cerebral ischemia. We asked whether (i) the two molecules are similarly 
      upregulated among non-lacunar and lacunar diabetic strokes and (ii) sCD40L and/or 
      MCP-1 predict the risk of cardiovascular events in this setting. METHODS: Ninety 
      patients with type 2 diabetes mellitus presenting with an acute ischemic stroke 
      (compared with 45 control subjects) were evaluated on admission and up to 36 
      months (median 24 months) after the event. RESULTS: Diabetic patients with acute 
      stroke had higher plasma CD40L and MCP-1 than controls (p<0.0001), with no 
      significant differences among lacunar and non-lacunar strokes. On multiple 
      regression analysis, only higher sCD40L quartiles and older age were associated 
      with higher MCP-1 quartiles. Forty-eight percent of patients experienced vascular 
      events. Cox regression analysis showed that only the presence of higher sCD40L 
      values independently predicted the recurrence of vascular events. CONCLUSION: 
      Up-regulation of inflammatory molecules, such as CD40L and MCP-1, is involved in 
      the advanced stage of atherosclerotic cerebro-vascular disease and is associated 
      with increased risk of recurrence of cardiovascular events.
FAU - Davi, Giovanni
AU  - Davi G
AD  - Department of Medicine and Aging, "G. d'Annunzio" University School of Medicine, 
      Chieti, Italy. gdavi@unich.it
FAU - Tuttolomondo, Antonino
AU  - Tuttolomondo A
FAU - Santilli, Francesca
AU  - Santilli F
FAU - Basili, Stefania
AU  - Basili S
FAU - Ferrante, Elisabetta
AU  - Ferrante E
FAU - Di Raimondo, Domenico
AU  - Di Raimondo D
FAU - Pinto, Antonio
AU  - Pinto A
FAU - Licata, Giuseppe
AU  - Licata G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090916
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Aged
MH  - CD40 Ligand/*biosynthesis
MH  - Chemokine CCL2/*biosynthesis
MH  - Cohort Studies
MH  - Diabetes Complications/*blood
MH  - Diabetes Mellitus/*blood
MH  - Female
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Risk
MH  - Stroke/*blood/*complications
MH  - Treatment Outcome
EDAT- 2009/09/17 06:00
MHDA- 2010/04/03 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - JST.JSTAGE/jat/1537 [pii]
AID - 10.5551/jat.1537 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2009;16(6):707-13. doi: 10.5551/jat.1537. Epub 2009 Sep 16.