PMID- 19755933 OWN - NLM STAT- MEDLINE DCOM- 20100325 LR - 20211020 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 67 IP - 1 DP - 2010 Jan TI - Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants. PG - 77-82 LID - 10.1203/PDR.0b013e3181c0b16c [doi] AB - Matrix metalloproteinases (MMPs) and chemokines seem to be induced by hyperoxia in preclinical studies. We hypothesized that O2 exposure immediately after birth is associated with altered blood spot MMP 9 and beta chemokine concentrations. The following analytes were measured on blood spots on d 1 and 3 of life, using luminex technology in 1059 infants (birth weights <1000 g) in the NICHD Neonatal Research Network: MMP 9, monocyte chemoattractant protein 1 (MCP 1), macrophage inflammatory proteins (1alpha and beta), and regulated upon activation, normal t cell expressed and secreted (RANTES). Infants administered O2 continually from 6 to 24 h of life (n = 729), when compared with those with <6 h exposure (n = 330), had significantly lower mean birth weight and higher rate of respiratory distress syndrome (p < 0.002). On d 3, MCP 1 was higher and RANTES lower among infants with early prolonged O2 exposure. After adjusting for covariates, prolonged early O2 exposure retained a statistically significant association with higher MCP 1 on d 3 (p = 0.003). The consistent association between O2 exposure and MCP 1 among extremely preterm infants suggests that further investigation of its role in oxidative injury is warranted. FAU - Natarajan, Girija AU - Natarajan G AD - Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. gnatara@med.wayne.edu FAU - Shankaran, Seetha AU - Shankaran S FAU - McDonald, Scott A AU - McDonald SA FAU - DAS, Abhik AU - DAS A FAU - Stoll, Barbara J AU - Stoll BJ FAU - Higgins, Rosemary D AU - Higgins RD FAU - Thorsen, Poul AU - Thorsen P FAU - Skogstrand, Kristin AU - Skogstrand K FAU - Hougaard, David M AU - Hougaard DM FAU - Carlo, Waldemar A AU - Carlo WA CN - NICHD neonatal research network LA - eng GR - U10 HD27851/HD/NICHD NIH HHS/United States GR - U10 HD021385/HD/NICHD NIH HHS/United States GR - U10 HD34216/HD/NICHD NIH HHS/United States GR - U10 HD040492-01/HD/NICHD NIH HHS/United States GR - M01 RR 00750/RR/NCRR NIH HHS/United States GR - M01 RR 00039/RR/NCRR NIH HHS/United States GR - U10 HD027851/HD/NICHD NIH HHS/United States GR - U10 HD21397/HD/NICHD NIH HHS/United States GR - UL1 RR025008/RR/NCRR NIH HHS/United States GR - M01 RR000125/RR/NCRR NIH HHS/United States GR - U10 HD027856/HD/NICHD NIH HHS/United States GR - U10 HD40689/HD/NICHD NIH HHS/United States GR - U10 HD021373/HD/NICHD NIH HHS/United States GR - U10 HD027880-09/HD/NICHD NIH HHS/United States GR - U10 HD027856-09/HD/NICHD NIH HHS/United States GR - U10 HD021397-14/HD/NICHD NIH HHS/United States GR - U10 HD027904-09/HD/NICHD NIH HHS/United States GR - R03 HD054420/HD/NICHD NIH HHS/United States GR - M01 RR 00125/RR/NCRR NIH HHS/United States GR - U10 HD40492/HD/NICHD NIH HHS/United States GR - U10 HD021373-15/HD/NICHD NIH HHS/United States GR - U10 HD027880/HD/NICHD NIH HHS/United States GR - U10 HD36790/HD/NICHD NIH HHS/United States GR - M01 RR 08084/RR/NCRR NIH HHS/United States GR - U10 HD040461-01/HD/NICHD NIH HHS/United States GR - U10 HD040521/HD/NICHD NIH HHS/United States GR - M01 RR000039/RR/NCRR NIH HHS/United States GR - U10 HD40521/HD/NICHD NIH HHS/United States GR - U10 HD27880/HD/NICHD NIH HHS/United States GR - M01 RR008084/RR/NCRR NIH HHS/United States GR - U10 HD27904/HD/NICHD NIH HHS/United States GR - U10 HD040461/HD/NICHD NIH HHS/United States GR - U10 HD27871/HD/NICHD NIH HHS/United States GR - M01 RR000044/RR/NCRR NIH HHS/United States GR - M01 RR000750/RR/NCRR NIH HHS/United States GR - U10 HD040521-01/HD/NICHD NIH HHS/United States GR - U10 HD027871-09/HD/NICHD NIH HHS/United States GR - U10 HD040689/HD/NICHD NIH HHS/United States GR - U10 HD040492/HD/NICHD NIH HHS/United States GR - U10 HD040689-06/HD/NICHD NIH HHS/United States GR - U10 HD034216-04/HD/NICHD NIH HHS/United States GR - U10 HD027853/HD/NICHD NIH HHS/United States GR - U10 HD027904/HD/NICHD NIH HHS/United States GR - U10 HD021397/HD/NICHD NIH HHS/United States GR - U10 HD27856/HD/NICHD NIH HHS/United States GR - U10 HD27853/HD/NICHD NIH HHS/United States GR - U10 HD40461/HD/NICHD NIH HHS/United States GR - UG1 HD034216/HD/NICHD NIH HHS/United States GR - UL1 TR000454/TR/NCATS NIH HHS/United States GR - 5 M01 RR00044/RR/NCRR NIH HHS/United States GR - U10 HD027871/HD/NICHD NIH HHS/United States GR - U10 HD027853-16/HD/NICHD NIH HHS/United States GR - M01 RR 00070/RR/NCRR NIH HHS/United States GR - M01 RR 0039-43/RR/NCRR NIH HHS/United States GR - U10 HD21373/HD/NICHD NIH HHS/United States GR - U10 HD036790-11/HD/NICHD NIH HHS/United States GR - M01 RR000070/RR/NCRR NIH HHS/United States GR - U10 HD21385/HD/NICHD NIH HHS/United States GR - U10 HD034216/HD/NICHD NIH HHS/United States GR - U10 HD036790/HD/NICHD NIH HHS/United States GR - U10 HD027851-09/HD/NICHD NIH HHS/United States GR - U10 HD021385-14/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 RN - 0 (Chemokines, CC) RN - EC 3.4.24.35 (Matrix Metalloproteinase 9) SB - IM MH - Chemokines, CC/*metabolism MH - Enzyme-Linked Immunosorbent Assay MH - Humans MH - *Infant, Extremely Low Birth Weight MH - Infant, Newborn MH - Matrix Metalloproteinase 9/*metabolism PMC - PMC2831535 MID - NIHMS161271 EDAT- 2009/09/17 06:00 MHDA- 2010/03/26 06:00 PMCR- 2011/01/01 CRDT- 2009/09/17 06:00 PHST- 2009/09/17 06:00 [entrez] PHST- 2009/09/17 06:00 [pubmed] PHST- 2010/03/26 06:00 [medline] PHST- 2011/01/01 00:00 [pmc-release] AID - 10.1203/PDR.0b013e3181c0b16c [doi] PST - ppublish SO - Pediatr Res. 2010 Jan;67(1):77-82. doi: 10.1203/PDR.0b013e3181c0b16c.