PMID- 19756706
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20211020
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 108
IP  - 1
DP  - 2010 Jan
TI  - Hypoxic training increases metabolic enzyme activity and composition of 
      alpha-myosin heavy chain isoform in rat ventricular myocardium.
PG  - 105-11
LID - 10.1007/s00421-009-1189-0 [doi]
AB  - Cardiac muscle adaptation is essential for maintaining physical capacity after 
      ascending to high altitude. This study examines the effects of high altitude 
      training on myocardial metabolic enzyme activity and composition of alpha-myosin 
      heavy chain (MHC). Rats were randomly divided into normobaric sedentary (NS) and 
      training (NT) groups, and hypobaric sedentary (HS) and training (HT) groups. HS 
      and HT rats were exposed to hypobaric hypoxia (simulated 4,000-5,000 m) for 5 
      weeks (24 h/day), and HT rats simultaneously received swim training. Hypoxia 
      exposure for 5 weeks led to a decrease in succinate dehydrogenase (SDH) and 
      citrate synthase (CS) activities in the left ventricle (LV), and a decrease in 
      CS, hexokinase (HK) and total lactate dehydrogenase (LDH) activities in the right 
      ventricle (RV) (p < 0.05, HS vs. NS). Furthermore, 1 h/day swim training during 
      hypoxia exposure enhanced the CS activity in LV and the SDH and CS activities in 
      RV (p < 0.05, HT vs. HS). The percentages of alpha-MHC in both ventricles in HT 
      were higher than those in HS (p < 0.05). We conclude that exercise training at 
      high altitude is beneficial for cardiac muscle adaptation to hypoxia by 
      increasing activities of enzymes and percentage of alpha-MHC. This may contribute 
      to improved cardiac function and work capacity at high altitude.
FAU - Cai, Ming-Chun
AU  - Cai MC
AD  - Department of Pathophysiology and High Altitude Physiology, Key Laboratory of 
      High Altitude Medicine, Ministry of Educative, Third Military Medical University, 
      Chongqing, China.
FAU - Huang, Qing-Yuan
AU  - Huang QY
FAU - Liao, Wei-Gong
AU  - Liao WG
FAU - Wu, Zhou
AU  - Wu Z
FAU - Liu, Fu-Yu
AU  - Liu FY
FAU - Gao, Yu-Qi
AU  - Gao YQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090916
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
RN  - EC 3.6.4.1 (Myosins)
SB  - IM
MH  - Adaptation, Physiological
MH  - Altitude Sickness
MH  - Analysis of Variance
MH  - Animals
MH  - Citrate (si)-Synthase/metabolism
MH  - Humans
MH  - Hypoxia/*enzymology/metabolism/*physiopathology
MH  - Male
MH  - Myocardium/pathology
MH  - Myosin Heavy Chains/*metabolism
MH  - Myosins/physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Succinate Dehydrogenase/metabolism
EDAT- 2009/09/17 06:00
MHDA- 2010/05/01 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/08/25 00:00 [accepted]
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - 10.1007/s00421-009-1189-0 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2010 Jan;108(1):105-11. doi: 10.1007/s00421-009-1189-0. Epub 
      2009 Sep 16.