PMID- 19757386
OWN - NLM
STAT- MEDLINE
DCOM- 20100331
LR  - 20100108
IS  - 1696-3547 (Electronic)
IS  - 0214-6282 (Linking)
VI  - 54
IP  - 2-3
DP  - 2010
TI  - Immunoregulatory molecules in human placentas: potential for diverse roles in 
      pregnancy.
PG  - 457-67
LID - 10.1387/ijdb.082831jh [doi]
AB  - Molecules with immunological functions abound in hemochorial mammalian placentas 
      where maternal blood and tissues are in direct contact with fetal placental 
      cells. For the most part, investigators have focused on the possibility that 
      these molecules are primarily in place for the purpose of preventing maternal 
      immune mechanisms from attacking the genetically different fetal cells. Yet 
      information collected in recent years indicates that these immunological 
      mediators may serve other, non-immunological functions in placentas. In this 
      article we discuss two families of these molecules investigated in our and other 
      laboratories, namely the tumor necrosis factor superfamily (TNFSF) and the human 
      leukocyte antigen (HLA) family, and present accumulating evidence for dichotomy 
      of function during gestation.
FAU - Hunt, Joan S
AU  - Hunt JS
AD  - Department of Anatomy and Cell Biology, The University of Kansas Medical Center, 
      Kansas, USA. jhunt@kumc.edu
FAU - Pace, Judith L
AU  - Pace JL
FAU - Gill, Ryan M
AU  - Gill RM
LA  - eng
GR  - R01HD24212/HD/NICHD NIH HHS/United States
GR  - R01HD29156/HD/NICHD NIH HHS/United States
GR  - U54 HD33994/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Spain
TA  - Int J Dev Biol
JT  - The International journal of developmental biology
JID - 8917470
RN  - 0 (HLA Antigens)
RN  - 0 (Tumor Necrosis Factors)
SB  - IM
MH  - Cell Differentiation/immunology
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Major Histocompatibility Complex/*immunology
MH  - Maternal-Fetal Exchange/immunology
MH  - Placenta/*immunology
MH  - Pregnancy
MH  - Tumor Necrosis Factors/*immunology
RF  - 73
EDAT- 2009/09/17 06:00
MHDA- 2010/04/01 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2010/04/01 06:00 [medline]
AID - 082831jh [pii]
AID - 10.1387/ijdb.082831jh [doi]
PST - ppublish
SO  - Int J Dev Biol. 2010;54(2-3):457-67. doi: 10.1387/ijdb.082831jh.