PMID- 19758099
OWN - NLM
STAT- MEDLINE
DCOM- 20091029
LR  - 20131121
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 200
IP  - 8
DP  - 2009 Oct 15
TI  - 3,4-Methylenedioxymethamphetamine increases susceptibility to genital herpes 
      simplex virus infection in mice.
PG  - 1247-50
LID - 10.1086/605891 [doi]
AB  - Abused by >1.2 million Americans, 3,4-methylenedioxymethamphetamine (MDMA) 
      (commonly referred to as ecstasy) is popular in the dance club, rave, and circuit 
      party scenes. MDMA and other similar drugs are reportedly associated with 
      increased incidence of sexually transmitted infectious diseases, such as AIDS and 
      genital herpes, and may have immunological effects. In the present study, we 
      demonstrate that MDMA causes increased susceptibility to herpes simplex virus 
      type 2 infection in mice and earlier onset of genital herpes. We also demonstrate 
      that MDMA has an effect on the cytokines of the innate immune system-both 
      systemically and, for the first time, in the genital tract. These data suggest 
      that MDMA may play an important biological role in infection.
FAU - Pennock, Jeffry W
AU  - Pennock JW
AD  - Department of Microbiology and Immunology, University of Texas Medical Branch, 
      Galveston 77555, USA.
FAU - Stegall, Rachael
AU  - Stegall R
FAU - Bubar, Marcy J
AU  - Bubar MJ
FAU - Milligan, Gregg
AU  - Milligan G
FAU - Cunningham, Kathryn A
AU  - Cunningham KA
FAU - Bourne, Nigel
AU  - Bourne N
LA  - eng
GR  - K05 DA020087/DA/NIDA NIH HHS/United States
GR  - R01 A1052372/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Cytokines)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Cytokines/blood/metabolism
MH  - Disease Susceptibility/*chemically induced
MH  - Female
MH  - Herpes Genitalis/*immunology
MH  - *Herpesvirus 2, Human
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mucous Membrane/metabolism
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Vagina/metabolism
EDAT- 2009/09/18 06:00
MHDA- 2009/10/30 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2009/10/30 06:00 [medline]
AID - 10.1086/605891 [doi]
PST - ppublish
SO  - J Infect Dis. 2009 Oct 15;200(8):1247-50. doi: 10.1086/605891.