PMID- 19758154
OWN - NLM
STAT- MEDLINE
DCOM- 20091029
LR  - 20220410
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1173
DP  - 2009 Sep
TI  - Cognitive functioning in Behcet's disease.
PG  - 217-26
LID - 10.1111/j.1749-6632.2009.04670.x [doi]
AB  - The impact of Behcet's disease on higher cognitive functions is still poorly 
      understood. We proposed (1) to characterize the neuropsychological profile of 
      Behcet's disease patients with (Neuro-BD) and without (BD) neurological 
      manifestations; (2) to identify which clinical, psychopathological, and genetic 
      variables are related to neuropsychological performance; and (3) to explore the 
      association between cognitive functioning and neuroimaging findings in BD 
      patients. Fifteen Neuro-BD and 35 BD patients in the nonactive phase of their 
      illness underwent a neurological examination, performed a comprehensive battery 
      of neuropsychological tests, and answered the hospital anxiety and depression 
      scale. Human leukocyte antigen (HLA)-B*51 genotyping was also performed. 
      Patients' neuropsychological performances were compared to those of healthy 
      demographically matched subjects. Within one month from the testing date, a 
      subset of 20-BD patients underwent a magnetic resonance imaging (MRI) scan. 
      Fifty-three percent of Neuro-BD and 40% of BD patients were impaired at least on 
      one neuropsychological measure (i.e., digit span-forward). Poorer cognitive 
      functioning in Neuro-BD was associated with parenchymal involvement, whereas in 
      BD it was related to presence of white matter changes in the frontal lobes, 
      history of headache complaints, or higher levels of anxiety and depression. 
      Current prednisone intake had a positive impact on neuropsychological 
      performance. Disease duration, time since onset of neurological manifestations, 
      or presence of HLA-B*51 allele had no significant influence. Our results indicate 
      that Behcet's disease may affect cognitive abilities in the absence of overt 
      neurological symptoms. These findings point to an insidious course of 
      neurological involvement.
FAU - Cavaco, Sara
AU  - Cavaco S
AD  - Laboratory of Neurobiology of Human Behavior, Centro Hospitalar do Porto-Hospital 
      de S. Antonio, Porto, Portugal. saracavaco@yahoo.com
FAU - da Silva, Ana Martins
AU  - da Silva AM
FAU - Pinto, Pedro
AU  - Pinto P
FAU - Coutinho, Ester
AU  - Coutinho E
FAU - Santos, Ernestina
AU  - Santos E
FAU - Bettencourt, Andreia
AU  - Bettencourt A
FAU - Pinto, Claudia
AU  - Pinto C
FAU - Goncalves, Alexandra
AU  - Goncalves A
FAU - Silva, Susana
AU  - Silva S
FAU - Gomes, Filomena
AU  - Gomes F
FAU - Carvalho, Luisa
AU  - Carvalho L
FAU - Pereira, Claudia
AU  - Pereira C
FAU - Martins, Berta
AU  - Martins B
FAU - Correia, Joao
AU  - Correia J
FAU - Vasconcelos, Carlos
AU  - Vasconcelos C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Behcet Syndrome/genetics/*physiopathology/*psychology
MH  - Brain/pathology/physiopathology
MH  - Cognition/*physiology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-B Antigens/genetics
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory/physiology
MH  - Middle Aged
MH  - Neurologic Examination
MH  - Neuropsychological Tests
MH  - Psychomotor Performance/*physiology
MH  - Verbal Learning/physiology
MH  - Word Association Tests
EDAT- 2009/09/18 06:00
MHDA- 2009/10/30 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2009/10/30 06:00 [medline]
AID - NYAS4670 [pii]
AID - 10.1111/j.1749-6632.2009.04670.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2009 Sep;1173:217-26. doi: 10.1111/j.1749-6632.2009.04670.x.