PMID- 19758166
OWN - NLM
STAT- MEDLINE
DCOM- 20091029
LR  - 20220224
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1173
DP  - 2009 Sep
TI  - IL-18 activity in systemic lupus erythematosus.
PG  - 301-9
LID - 10.1111/j.1749-6632.2009.04742.x [doi]
AB  - Interleukin-18 (IL-18) is an inflammation-related cytokine that plays a central 
      role both in innate defense reactions and in Th1 activation and specific immune 
      responses. Increased levels of IL-18 can be detected in biological fluids and 
      organs of individuals affected by several autoimmune pathologies, as well as in 
      autoimmune animal models. In this review, the role of IL-18 in systemic lupus 
      erythematosus (SLE) is critically examined, including its possible role in the 
      pathogenesis of disease. In SLE, increased levels of IL-18 have been found in 
      serum/plasma of affected persons, which positively correlated with disease 
      severity. The possibility that circulating IL-18 levels are predictive of renal 
      damage has been proposed, suggesting that IL-18 may be a prognostic marker of 
      renal involvement useful to identify patients at risk of renal failure. The 
      evaluation of urinary levels of free active IL-18 indeed suggests a correlation 
      with the degree of renal involvement. The possible pathogenic role of IL-18 in 
      lupus has been studied in a mouse model of progressive disease, which makes 
      possible the identification, at the level of the different affected organs, of 
      IL-18 changes preceding disease development and those appearing after disease 
      onset. It can be concluded that IL-18 has a multifaceted role in autoimmune 
      lupus, being apparently involved both in the effector phases of the late organ 
      damage and, in some organs, in the initial pathogenic events. Therapeutic 
      strategies targeting IL-18 in autoimmunity are under development.
FAU - Favilli, Flavia
AU  - Favilli F
AD  - National Research Council, Institute of Biomedical Technologies, Pisa, Italy. 
      flavia.favilli@itb.cnr.it
FAU - Anzilotti, Consuelo
AU  - Anzilotti C
FAU - Martinelli, Lucia
AU  - Martinelli L
FAU - Quattroni, Paola
AU  - Quattroni P
FAU - De Martino, Salvatore
AU  - De Martino S
FAU - Pratesi, Federico
AU  - Pratesi F
FAU - Neumann, Detlef
AU  - Neumann D
FAU - Beermann, Silke
AU  - Beermann S
FAU - Novick, Daniela
AU  - Novick D
FAU - Dinarello, Charles A
AU  - Dinarello CA
FAU - Boraschi, Diana
AU  - Boraschi D
FAU - Migliorini, Paola
AU  - Migliorini P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-16)
RN  - 0 (interleukin-18 binding protein)
SB  - IM
MH  - Animals
MH  - Gene Expression Profiling
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/genetics/metabolism
MH  - Interleukin-16/blood/genetics/*metabolism
MH  - Kidney/metabolism
MH  - Lupus Erythematosus, Systemic/blood/genetics/*metabolism
MH  - Lymph Nodes/metabolism
MH  - Mice
MH  - Mice, Inbred MRL lpr
EDAT- 2009/09/18 06:00
MHDA- 2009/10/30 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2009/10/30 06:00 [medline]
AID - NYAS4742 [pii]
AID - 10.1111/j.1749-6632.2009.04742.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2009 Sep;1173:301-9. doi: 10.1111/j.1749-6632.2009.04742.x.