PMID- 19758195
OWN - NLM
STAT- MEDLINE
DCOM- 20091029
LR  - 20220408
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1173
DP  - 2009 Sep
TI  - Genetic susceptibility loci in rheumatoid arthritis establish transcriptional 
      regulatory networks with other genes.
PG  - 521-37
LID - 10.1111/j.1749-6632.2009.04629.x [doi]
AB  - Linkage studies have identified the human leukocyte antigen (HLA)-DRB1 as a 
      putative rheumatoid arthritis (RA) susceptibility locus (SL). Nevertheless, it 
      was estimated that its contribution was partial, suggesting that other non-HLA 
      genes may play a role in RA susceptibility. To test this hypothesis, we conducted 
      microarray transcription profiling of peripheral blood mononuclear cells in 15 RA 
      patients and analyzed the data, using bioinformatics programs (significance 
      analysis of microarrays method and GeneNetwork), which allowed us to determine 
      the differentially expressed genes and to reconstruct transcriptional networks. 
      The patients were grouped according to disease features or treatment with tumor 
      necrosis factor blocker. Transcriptional networks that were reconstructed allowed 
      us to identify the interactions occurring between RA SL and other genes, for 
      example, HLA-DRB1 interacting with FNDC3A (fibronectin type III domain containing 
      3A). Given that fibronectin fragments can stimulate mediators of matrix and 
      cartilage destruction in RA, this interaction is of special interest and may 
      contribute to a clearer understanding of the functional role of HLA-DRB1 in RA 
      pathogenesis.
FAU - Silva, Guilherme Liberato
AU  - Silva GL
AD  - Molecular Immunogenetics Group, Department of Genetics, University of Sao Paulo, 
      Ribeirao Preto, Brazil.
FAU - Junta, Cristina Moraes
AU  - Junta CM
FAU - Sakamoto-Hojo, Elza Tiemi
AU  - Sakamoto-Hojo ET
FAU - Donadi, Eduardo Antonio
AU  - Donadi EA
FAU - Louzada-Junior, Paulo
AU  - Louzada-Junior P
FAU - Passos, Geraldo A S
AU  - Passos GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (cyclic citrullinated peptide)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics/immunology
MH  - Autoantibodies/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *Gene Expression Profiling
MH  - Gene Regulatory Networks/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA-DR Antigens/genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Models, Genetic
MH  - Oligonucleotide Array Sequence Analysis/methods
MH  - Peptides, Cyclic/immunology
EDAT- 2009/09/18 06:00
MHDA- 2009/10/30 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2009/10/30 06:00 [medline]
AID - NYAS4629 [pii]
AID - 10.1111/j.1749-6632.2009.04629.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2009 Sep;1173:521-37. doi: 10.1111/j.1749-6632.2009.04629.x.