PMID- 19758266
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20120314
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Jul-Aug
TI  - Patient HSP70-hom TG haplotype is associated with decreased transplant-related 
      mortality and improved survival after sibling HLA-matched hematopoietic stem cell 
      transplantation.
PG  - 459-66
LID - 10.1111/j.1399-0012.2009.01094.x [doi]
AB  - Heat shock protein 70-hom (HSP70-hom) plays an important role in protein folding 
      and immune responses. Therefore, HSP70-hom gene polymorphisms may act as 
      important factors in predicting the prognosis of patients receiving allogeneic 
      hematopoietic stem cell transplantation (HSCT). To evaluate the role of HSP70-hom 
      gene polymorphisms in the prognosis of patients receiving sibling human leukocyte 
      antigen (HLA)-matched allogeneic HSCT, the HSP70-hom polymorphisms, T2437C and 
      G2763A, were genotyped in 147 patients receiving sibling HLA-matched allogeneic 
      HSCT. Individual diplotypes were estimated from genotype data of the two 
      HSP70-hom polymorphisms using the expectation maximization algorithm. Patients 
      with the 2763GG or GA genotype showed longer overall survival compared with those 
      with the 2763AA genotype, and patients with a TG haplotype (TG/TA, TG/TG or 
      TG/CG) also showed longer overall survival compared with those with a non-TG 
      haplotype (TA/TA or TA/CG) (both G2763A genotype and diplotype, p<0.01). 
      Moreover, the 2437TT genotype was found to be protective for treatment-related 
      death compared with the 2437TC genotype, and a TG haplotype was found to be very 
      protective for treatment-related death compared with a non-TG haplotype (T2437C 
      genotype, p=0.04; and diplotype, p=0.02). Therefore, our results suggest that 
      HSP70-hom polymorphisms play an important role in the prognosis of patients 
      receiving sibling HLA-matched allogeneic HSCT.
CI  - (c) 2009 John Wiley & Sons A/S.
FAU - Kim, Inho
AU  - Kim I
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Kim, Jin Hee
AU  - Kim JH
FAU - Rhee, Ji Young
AU  - Rhee JY
FAU - Kim, Jin Won
AU  - Kim JW
FAU - Cho, Hyeon Jin
AU  - Cho HJ
FAU - Cho, Eun-Young
AU  - Cho EY
FAU - Lee, Jong-Eun
AU  - Lee JE
FAU - Hong, Yun-Chul
AU  - Hong YC
FAU - Park, Sung Sup
AU  - Park SS
FAU - Yoon, Sung-Soo
AU  - Yoon SS
FAU - Park, Myoung Hee
AU  - Park MH
FAU - Park, Seonyang
AU  - Park S
FAU - Kim, Byoung Kook
AU  - Kim BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (HLA Antigens)
RN  - 0 (HSP70 Heat-Shock Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Graft vs Host Disease/*genetics/*mortality/prevention & control
MH  - HLA Antigens/*genetics
MH  - HSP70 Heat-Shock Proteins/*genetics
MH  - Haplotypes/*genetics
MH  - Hematologic Neoplasms/genetics/*mortality/therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Siblings
MH  - Survival Rate
MH  - Young Adult
EDAT- 2009/09/18 06:00
MHDA- 2011/02/02 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - CTR1094 [pii]
AID - 10.1111/j.1399-0012.2009.01094.x [doi]
PST - ppublish
SO  - Clin Transplant. 2010 Jul-Aug;24(4):459-66. doi: 
      10.1111/j.1399-0012.2009.01094.x.