PMID- 19758406 OWN - NLM STAT- MEDLINE DCOM- 20100701 LR - 20220408 IS - 1601-0825 (Electronic) IS - 1354-523X (Linking) VI - 16 IP - 3 DP - 2010 Apr TI - Immune reconstitution inflammatory syndrome after highly active antiretroviral therapy: a review. PG - 248-56 LID - 10.1111/j.1601-0825.2009.01628.x [doi] AB - The use of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV) restores immune responses against pathogens and has greatly decreased mortality. However, in about 25% to 35% of patients receiving HAART, the reconstituted immune system leads to a pathological inflammatory response, commonly known as immune reconstitution inflammatory syndrome (IRIS), which causes substantial short-term morbidity or even mortality. Although we have gleaned some knowledge on IRIS in the past few years, a number of unanswered questions remain. In this review, we discuss the definition, diagnostic criteria, pathogenesis, risk factors, clinical spectrum including oral manifestations, and management of IRIS. FAU - Tsang, C S P AU - Tsang CS AD - Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong SAR, China. csptsang@hkucc.hku.hk FAU - Samaranayake, L P AU - Samaranayake LP LA - eng PT - Journal Article PT - Review DEP - 20090916 PL - Denmark TA - Oral Dis JT - Oral diseases JID - 9508565 MH - AIDS-Related Opportunistic Infections/*complications MH - Antiretroviral Therapy, Highly Active/adverse effects MH - Candidiasis, Oral/complications MH - Herpes Zoster/complications MH - Humans MH - *Immune Reconstitution Inflammatory Syndrome/complications/diagnosis/etiology/therapy MH - Mouth Diseases/*complications MH - Mouth Neoplasms/complications MH - Risk Factors MH - Sarcoma, Kaposi/complications RF - 88 EDAT- 2009/09/18 06:00 MHDA- 2010/07/02 06:00 CRDT- 2009/09/18 06:00 PHST- 2009/09/18 06:00 [entrez] PHST- 2009/09/18 06:00 [pubmed] PHST- 2010/07/02 06:00 [medline] AID - ODI1628 [pii] AID - 10.1111/j.1601-0825.2009.01628.x [doi] PST - ppublish SO - Oral Dis. 2010 Apr;16(3):248-56. doi: 10.1111/j.1601-0825.2009.01628.x. Epub 2009 Sep 16.