PMID- 19758705 OWN - NLM STAT- MEDLINE DCOM- 20091117 LR - 20220311 IS - 0165-1781 (Print) IS - 0165-1781 (Linking) VI - 169 IP - 3 DP - 2009 Oct 30 TI - Comparative study of neurocognitive function in euthymic bipolar patients and stabilized schizophrenic patients. PG - 220-8 LID - 10.1016/j.psychres.2008.06.032 [doi] AB - Few studies have compared neurocognitive performance in euthymic patients with bipolar disorder (BD), stabilized patients with schizophrenia (SC) and normal controls (NC) using a comprehensive neuropsychological battery, and those that have been conducted have yielded discrepant results. We evaluated the neurocognitive profile shown by 73 euthymic patients with BD, 89 stabilized patients with SC and 67 NC. All participants completed a cognitive battery in which the domains evaluated were executive functioning, sustained attention, and verbal and visual memory. Individuals with BD were administered the Quality of Life Scale (QLS). Patients with BD manifested dysfunction in executive functioning (moderate-to-large effect size), sustained attention (moderate effect size) and verbal/visual memory (large effect size) compared with NC. Verbal memory deficit in patients with BD was related to poor functional outcome on the QLS and Global Assessment of Functioning (GAF). Patients with BD performed significantly better than patients with SC on the Trail Making Test (TMT) part B, backward digit span, and California Verbal Learning Test (CVLT) learning trials. Other neuropsychological measures showed no significant differences between the two patient groups. These findings support the notion that euthymic BD patients suffer from an extensive neurocognitive deficit that affects all cognitive domains and is qualitatively similar to that in SC patients. Persistent verbal memory impairment in BD has clinical relevance because it is associated with poor psychosocial function. FAU - Sanchez-Morla, Eva Maria AU - Sanchez-Morla EM AD - University General Hospital of Guadalajara, Spain. emsanchez@sescam.jccm.es FAU - Barabash, Ana AU - Barabash A FAU - Martinez-Vizcaino, Vicente AU - Martinez-Vizcaino V FAU - Tabares-Seisdedos, Rafael AU - Tabares-Seisdedos R FAU - Balanza-Martinez, Vicent AU - Balanza-Martinez V FAU - Cabranes-Diaz, Jose Antonio AU - Cabranes-Diaz JA FAU - Baca-Baldomero, Enrique AU - Baca-Baldomero E FAU - Gomez, Jose Luis Santos AU - Gomez JL LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090915 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Adolescent MH - Adult MH - Bipolar Disorder/*complications/*psychology MH - Chi-Square Distribution MH - Cognition Disorders/*etiology/psychology MH - Female MH - Humans MH - Male MH - Memory/physiology MH - Middle Aged MH - Multivariate Analysis MH - Neuropsychological Tests MH - Problem Solving/physiology MH - Psychiatric Status Rating Scales MH - Schizophrenia/*complications MH - *Schizophrenic Psychology MH - Young Adult EDAT- 2009/09/18 06:00 MHDA- 2009/11/18 06:00 CRDT- 2009/09/18 06:00 PHST- 2007/06/05 00:00 [received] PHST- 2008/01/09 00:00 [revised] PHST- 2008/06/13 00:00 [accepted] PHST- 2009/09/18 06:00 [entrez] PHST- 2009/09/18 06:00 [pubmed] PHST- 2009/11/18 06:00 [medline] AID - S0165-1781(08)00200-X [pii] AID - 10.1016/j.psychres.2008.06.032 [doi] PST - ppublish SO - Psychiatry Res. 2009 Oct 30;169(3):220-8. doi: 10.1016/j.psychres.2008.06.032. Epub 2009 Sep 15.