PMID- 19759317
OWN - NLM
STAT- MEDLINE
DCOM- 20091002
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 37
DP  - 2009 Sep 16
TI  - Voluntary motor output is altered by spike-timing-dependent changes in the human 
      corticospinal pathway.
PG  - 11708-16
LID - 10.1523/JNEUROSCI.2217-09.2009 [doi]
AB  - Repeated pairs of timed presynaptic and postsynaptic potentials cause lasting 
      changes in efficacy of transmission at many synapses. The corticospinal tract is 
      the major pathway controlling voluntary movement in humans, and corticospinal 
      neurons have monosynaptic connections to motoneurons of many muscles. We 
      hypothesized that corticospinal transmission in humans could be altered by 
      delivering, to the corticospinal-motoneuronal synapses, timed pairs of 
      presynaptic volleys (produced by cortical stimulation) and antidromic 
      postsynaptic volleys (by peripheral nerve stimulation). To test corticospinal 
      transmission, electrical cervicomedullary stimuli evoked motor responses 
      [cervicomedullary motor-evoked potentials (CMEPs)] in biceps brachii before and 
      for 1 h after conditioning with 50 paired cortical and peripheral nerve stimuli. 
      Seven interstimulus intervals (ISIs) of conditioning stimulus pairs were tested 
      on different days. With one ISI (+3 ms; cortical before peripheral nerve 
      stimulation), CMEPs were significantly increased in size by 33 +/- 30% (mean +/- 
      SD; n = 7) from 4 until 32 min after conditioning. With two other ISIs (-13 ms, 
      +22 ms), CMEPs were decreased from approximately 30 until 60 min after 
      conditioning (by 25 +/- 23% and 27 +/- 32%; n = 8). The remaining ISIs produced 
      no changes. In a second study, subjects performed weak bilateral voluntary elbow 
      flexion contractions before and after conditioning of the right elbow flexors. 
      Conditioning ISIs that increased or decreased CMEPs similarly increased or 
      decreased voluntary force and EMG on the right. Thus, depending on their timing, 
      repeated paired stimuli can potentiate or depress corticospinal transmission, and 
      these changes are functionally relevant. We suggest that bidirectional 
      spike-timing-dependent plasticity can be induced at corticospinal-motoneuronal 
      synapses and can influence voluntary motor output.
FAU - Taylor, Janet L
AU  - Taylor JL
AD  - Prince of Wales Medical Research Institute and University of New South Wales, 
      Sydney, New South Wales 2031, Australia. j.taylor@powmri.edu.au
FAU - Martin, Peter G
AU  - Martin PG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Afferent Pathways/physiology
MH  - Analysis of Variance
MH  - Electric Stimulation/methods
MH  - Electromyography/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Models, Neurological
MH  - Motor Neurons/*physiology
MH  - Movement/*physiology
MH  - Muscle Contraction/physiology
MH  - Muscle, Skeletal/physiology
MH  - Peripheral Nerves/physiology
MH  - Pyramidal Tracts/cytology/*physiology
MH  - Reaction Time/physiology
MH  - Synaptic Potentials/*physiology
MH  - Time Factors
MH  - Transcutaneous Electric Nerve Stimulation
MH  - Young Adult
PMC - PMC6665756
EDAT- 2009/09/18 06:00
MHDA- 2009/10/03 06:00
PMCR- 2010/03/16
CRDT- 2009/09/18 06:00
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2009/10/03 06:00 [medline]
PHST- 2010/03/16 00:00 [pmc-release]
AID - 29/37/11708 [pii]
AID - 3526972 [pii]
AID - 10.1523/JNEUROSCI.2217-09.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 Sep 16;29(37):11708-16. doi: 10.1523/JNEUROSCI.2217-09.2009.